UNC-926|UNC926|Kme reader domain inhibitor

Cas No.:	1184136-10-4
Chemical Name:	UNC-926 free base
Synonyms:	UNC-926 free base; UNC-926; UNC926; UNC 926.
SMILES:	C1CCN(C1)C2CCN(CC2)C(=O)C3=CC(=CC=C3)Br
Formula:	C₁₆H₂₁BrN₂O
M.Wt:	337.261
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

UNC-926 is a methyl-lysine (Kme) reader domain inhibitor; inhibits L3MBTL1 with an IC50 of 3.9 μM.

In Vitro:

UNC-926 inhibits L3MBTL1 with an IC50 of 3.9 μM. L3MBTL1UNC-926 also exhibits a low micromolar affinity for the close homolog, L3MBTL3, with a decrease in affinity for the other MBT domains and no binding to CBX7. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively inhibits the L3MBTL13xMBT-H4K20me1 interaction in a dose-dependent manner. UNC-926 does not have an effect on the binding of 53BP1 to H4K20me1, demonstrating specificity of UNC-926 for L3MBTL1 over 53BP1[1].

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