Cat. No. | Product name | CAS No. |
DC12145 |
DLinDMA
Featured
DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark. |
871258-12-7 |
DC12381 |
DLin-KC2-DMA
Featured
DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA. |
1190197-97-7 |
DC10800 |
DLin-MC3-DMA
Featured
D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA. |
1224606-06-7 |
DC31000 |
CIN16645
Featured
CIN-16645 is a cationic lipids useful in the delivery of biologically active agents to cells and tissues. CIN16645 may be useful for making lipid nanoparticle-based compound and useful for delivery of CRISPR/Cas gene editing components. CIN was reported in WO 2015095340 (Intellia Therapeutics). |
1799316-64-5 |
DC31001 |
ATX-081
Featured
ATX-081 is an ionizable cationic lipids for RNA or Gene delivery. |
2230211-82-0 |
DC31002 |
ATX-083
Featured
ATX-083 is an ionizable cationic lipids for RNA delivery. |
2230211-84-2 |
DC31003 |
ATX-084
Featured
ATX-084 is an ionizable cationic lipids for RNA or Gene delivery. |
2230647-08-0 |
DC31004 |
ATX-087
Featured
ATX-087 is a novel ionizable cationic lipids for RNA delivery. |
2230647-05-7 |
DC31024 |
Lipid 5
Featured
Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1]. |
2089251-33-0 |
DC40169 |
DMG-PEG 2000
Featured
DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles. |
160743-62-4 |
DC42537 |
ALC-0315
Featured
ALC-0315 is a cationic lipid extracted from patent WO2019202035A1, compound III-3. ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system). |
2036272-55-4 |
DC52020 |
ALC-0159
Featured
ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature. It has been deployed in the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine that contains the active ingredient tozinameran. |
1849616-42-7 |
DC52025 |
SM-102
Featured
SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles.Administration of luciferase mRNA in SM-102-containing lipid nanoparticles induces hepatic luciferase expression in mice. Formulations containing SM-102 have been used in the development of lipid nanoparticles for delivery of mRNA-based vaccines. |
2089251-47-6 |
DC52027 |
DOTAP(chloride)
Featured
1,2-Dioleoyl-3-trimethylammoniumpropane (DOTAP) is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. |
132172-61-3 |
DC52028 |
MVL5
Featured
MVL5 is a new Multivalent Cationic Lipid for siRNA Delivery.Improved total gene silencing and Lower non-specific gene silencing,Lower toxicity. |
464926-03-2 |