Home > Inhibitors & Agonists > Cationic Lipid
Cat. No. Product name CAS No.
DC12145 DLinDMA Featured

DLinDMA is a key lipid component of stable nucleic acid lipid particles as a benchmark.

871258-12-7
DC12381 DLin-KC2-DMA Featured

DLin-KC2-DMA is 100-fold and 1000-fold more potent, respectively, in silencing of a hepatic gene (Factor VII) in comparison to the previous generation lipid DLin-DMA.

1190197-97-7
DC10800 DLin-MC3-DMA Featured

D-Lin-MC3-DMA(MC3) is the most potent cationic lipid that has been synthesized for Lipid nanoparticles (LNPs) to deliver the siRNA.

1224606-06-7
DC31000 CIN16645 Featured

CIN-16645 is a cationic lipids useful in the delivery of biologically active agents to cells and tissues. CIN16645 may be useful for making lipid nanoparticle-​based compound and useful for delivery of CRISPR​/Cas gene editing components. CIN was reported in WO 2015095340 (Intellia Therapeutics).

1799316-64-5
DC31001 ATX-081 Featured

ATX-081 is an ionizable cationic lipids for RNA or Gene delivery.

2230211-82-0
DC31002 ATX-083 Featured

ATX-083 is an ionizable cationic lipids for RNA delivery.

2230211-84-2
DC31003 ATX-084 Featured

ATX-084 is an ionizable cationic lipids for RNA or Gene delivery.

2230647-08-0
DC31004 ATX-087 Featured

ATX-087 is a novel ionizable cationic lipids for RNA delivery.

2230647-05-7
DC31024 Lipid 5 Featured

Lipid 5 is an amino lipid that affords efficient mRNA delivery in rodent and primate models. Lipid 5 shows optimal pharmacokinetics and non-toxic side effects.Replacement of the linoleic tail with a primary ester-containing lipid tail (Lipid 5) provids increased expression and optimal tissue clearance. The metabolite identification studies with Lipid 5 indicated that hydrolysis of the primary ester is the first step in the metabolism of the lipid[1].Clearance of Lipid 5 and MC3 from multiple mouse tissues is measured after dosing 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. Liver and spleen have the highest levels of Lipid 5, however, significantly lower levels than MC3. Lipid 5 is detected in plasma, lung, and kidney, but not in heart[1].

2089251-33-0
DC33636 DOTAP Featured

DOTAP, also known as 1,2-Dioleoyl-3-trimethylammoniumpropane, is a cationic liposome-forming compound used for transfection of DNA, RNA, and other negatively charged molecules into eukaryotic cells. It has been used in gene delivery vectors for gene therapy

132172-61-3
DC40169 DMG-PEG 2000 Featured

DMG-PEG 2000 is used for the preparation of liposome for siRNA delivery with improved transfection efficiency in vitro. DMG-PEG 2000 is also used for the lipid nanoparticle for an oral plasmid DNA delivery approach in vivo through a facile surface modification to improve the mucus permeability and delivery efficiency of the nanoparticles.

160743-62-4
DC42537 ALC-0315 Featured

ALC-0315 is a cationic lipid extracted from patent WO2019202035A1, compound III-3. ALC-0315 can be used to form lipid nanoparticle (LNP, non-viral gene delivery system).

2036272-55-4
DC52020 ALC-0159 Featured

ALC-0159 is a PEG/lipid conjugate (i.e. PEGylated lipid), specifically, it is the N,N-dimyristylamide of 2-hydroxyacetic acid, O-pegylated to a PEG chain mass of about 2 kilodaltons (corresponding to about 45-46 ethylene oxide units per molecule of N,N-dimyristyl hydroxyacetamide). It is a non-ionic surfactant by its nature.

1849616-42-7
DC52025 SM-102 Featured

SM-102 is an ionizable amino lipid that has been used in combination with other lipids in the formation of lipid nanoparticles.Administration of luciferase mRNA in SM-102-containing lipid nanoparticles induces hepatic luciferase expression in mice. Formulations containing SM-102 have been used in the development of lipid nanoparticles for delivery of mRNA-based vaccines.

2089251-47-6
DC52028 MVL5 Featured

MVL5 is a new Multivalent Cationic Lipid for siRNA Delivery.Improved total gene silencing and Lower non-specific gene silencing,Lower toxicity.

464926-03-2
DC53130 93-O17S Featured

93-O17S is an imidazole-based synthetic lipidoid for in vivo mRNA delivery. Lipid nanoparticles (LNPs) with 93-O17S promotes both the cross-presentation of tumor antigens and the intracellular delivery of cGAMP (STING agonist).

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