p-Tolyl-β-D-glucuronide|CAS 17680-99-8|DC Chemicals

Cas No.:	17680-99-8
Chemical Name:	b-D-Glucopyranosiduronic acid,4-methylphenyl
Synonyms:	b-D-Glucopyranosiduronic acid,4-methylphenyl;P-TOLYL-BETA-D-GLUCURONIDE;(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methylphenoxy)oxane-2-carboxylic acid;4-Methylphenol glucuronide;A-D-glucuronic acid;A-D-glucuronide;p-methylphenyl glucuronide;p-Tolyl-;p-Cresol Glucuronide;p-Tolyl-β-D-glucuronide;p-Tolyl-β-D-glucuronic acid
SMILES:	CC1C=CC(O[C@@H]2O[C@H](C(=O)O)[C@@H](O)[C@H](O)[C@H]2O)=CC=1
Formula:	C₁₃H₁₆O₇
M.Wt:	284.26194
Sotrage:	-20
Publication:	1. Rong, Y., and Kiang, T.K.L. Characterizations of human UDP-glucuronosyltransferase enzymes in the conjugation of p-cresol. Toxicol. Sci. 176(2), 285-296 (2020). 2. Gryp, T., De Paepe, K., Vanholder, R., et al. Gut microbiota generation of protein-boun

Description:

p-Cresol glucuronide is a metabolite of p-cresol, a uremic toxin formed by bacterial fermentation of proteins in the large intestine. It is formed from p-cresol primarily by the UDP-glucuronosyltransferase (UGT) isoform UGT1A6, but also by UGT1A9, in human liver and kidney microsomes. p-Cresol glucuronide accumulates in feces, blood, and urine of patients with chronic kidney disease (CKD).

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2018-0101

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