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Aminopurvalanol A

  Cat. No.:  DC80011   Featured
Chemical Structure
220792-57-4
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More than 5000 active chemicals with high quality for research!
Field of application
Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 220792-57-4
Chemical Name: (R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-isopropyl-9H-purin-2-yl)amino)-3-methylbutan-1-ol
Synonyms: NG-97; NG97; NG 97; Aminopurvalanol A; Aminopurvalanol-A
SMILES: CC(C)[C@@H](NC1=NC(NC2=CC(Cl)=CC(N)=C2)=C3N=CN(C(C)C)C3=N1)CO
Formula: C19H26ClN7O
M.Wt: 403.92
Purity: >98%
Sotrage: -20
Publication: [1]. Bernabò N, et al. Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization. Front Physiol. 2017;8:1097. [2]. Rosania GR, et al. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc Natl Acad Sci U S A. 1999;96(9):4797-4802.
Description: Aminopurvalanol A is a potent, selective, and cell permeable inhibitor of Cyclins/Cdk complexes. Aminopurvalanol A preferentially targets the G2/M-phase transition inhibiting cancer cell differentiation. Aminopurvalanol A causes the inhibition of sperm fertilizing ability via the inhibition of physiological capacitation-dependent actin polymerization[1][2].
Target: Cyclins/Cdk[1]
In Vitro: Aminopurvalanol A (5 and 40 μM; 8 hours) inhibits cell growth primarily by arresting the cells in the G2 phase of the cell cycle and, at higher concentration, triggering apoptosis[2]. Cell Cycle Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: Increased the number of cells with a 4N DNA content as early as 8 h after the beginning of treatment at 5 μM. 40 μM led to cellular fragmentation and cells with an irregular DNA distribution, characteristic of apoptotic cell populations. Apoptosis Analysis[2] Cell Line: Human U937 leukemic cells Concentration: 5 and 40 μM Incubation Time: 8 hours Result: 40 μM Aminopurvalanol A led to apoptosis rather than after the beginning of treatment at 5 μM.
References: [1]. Bernabò N, et al. Aminopurvalanol A, a Potent, Selective, and Cell Permeable Inhibitor of Cyclins/Cdk Complexes, Causes the Reduction of in Vitro Fertilizing Ability of Boar Spermatozoa, by Negatively Affecting the Capacitation-Dependent Actin Polymerization. Front Physiol. 2017;8:1097. [2]. Rosania GR, et al. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts. Proc Natl Acad Sci U S A. 1999;96(9):4797-4802.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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