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Home > Inhibitors & Agonists > Wnt/Notch/Hedgehog > GSK-3

CP21 (CP21R7)

  Cat. No.:  DC9726   Featured
Chemical Structure
125314-13-8
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More than 5000 active chemicals with high quality for research!
Field of application
CP21R7 is a potent and selective GSK-3β inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 125314-13-8
Chemical Name: 3-(3-Aminophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione
Synonyms: CP21R7;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione;CP21;CP21R7(CP21);3-(3-Aminophenyl)-4-(1-methyl-1H-indol-3-yl)pyrrole-2,5-dione;3-(3-aminophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-;3-(3-Aminophenyl)-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione;3-(3-aminophenyl)-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione;Cp21r7 (cp21);(Phenylindolyl)maleimide deriv. 69;BDBM2647;HMS3401K10;CP21 (CP21R7);BCP17360;MFC
SMILES: O=C1C(=C(C(N1[H])=O)C1C([H])=C([H])C([H])=C(C=1[H])N([H])[H])C1=C([H])N(C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12
Formula: C19H15N3O2
M.Wt: 317.3413
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CP21R7 is potent GSK-3β inhibitor, with an IC50 of 1.8 nM; CP21R7 also shows inhibitory activitiy against PKCα, with an IC50 of 1900 nM.
In Vitro: CP21R7 (Compound 9) is a selective inhibitor of GSK-3β, with an IC50 of 1.8 nM; the IC50 of CP21R7 against PKCα is 1900 nM[1]. CP21R7 (CP21, 3 μM) potently activates canonical Wnt signaling with highest activity. CP21 significantly increases total levels of intracellular β-catenin. CP21 combined with BMP4 induces commitment of hPSCs towards mesoderm[2].
References: [1]. Gong L, et al. Discovery of potent and bioavailable GSK-3beta inhibitors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1693-6. [2]. Patsch C, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nat Cell Biol. 2015 Aug;17(8):994-1003.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC71176 TC-G 24 TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM.
DC7004 AR-A014418(GSK3β Inhibitor VIII) AR-A014418 is a selective and effective GSK3β inhibitor with an IC 50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.
DC1063 TWS119 TWS119 is a GSK-3β inhibitor with IC50 of 30 nM.
DC7680 IM-12 The GSK3β Inhibitor XIX, IM-12 is a selective GSK-3β inhibitor with IC50 of 53 nM, and also enhances canonical Wnt signalling.
DC4227 SB216763 SB 216763 is a potent and selective cell permeable ATP-competitive inhibitor of GSK3α with an IC50 value of 34 nM (similar potency for GSK3β).
DC9726 CP21 (CP21R7) CP21R7 is a potent and selective GSK-3β inhibitor.
DC1023 CHIR-99021 (CT99021) CHIR-99021 is a glycogen synthase kinase 3 beta inhibitor that has antiproliferative activity in vitro and in vivo.
DC9703 CHIR-99021 HCl CHIR-99021 HCl is a potent and selective inhibitor of glycogen synthase kinase 3 beta (GSK-3β), a key enzyme involved in regulating various cellular processes, including metabolism, cell proliferation, and differentiation. By inhibiting GSK-3β, CHIR-99021 HCl modulates downstream signaling pathways, particularly the Wnt/β-catenin pathway, leading to significant biological effects both in vitro and in vivo.
DC7384 CHIR-98014 CHIR-98014 is a potent GSK-3α/β inhibitor with IC50 of 0.65 nM/0.58 nM, with the ability to distinguish GSK-3 from its closest homologs Cdc2 and ERK2.
DC7663 BIO BIO (6-bromoindirubin-3'-oxime) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β, shows >16-fold selectivity over CDK5, also a pan-JAKinhibitor.
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