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| Cas No.: | 252003-65-9 |
| Chemical Name: | 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide |
| Synonyms: | 3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide;CP-547632;3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-(4-pyrrolidin-1-ylbutylcarbamoylamino)-1,2-thiazole-4-carboxamide;3-[(4-Bromo-2,6-difluorophenyl)methoxy]-5-[[[[4-(1-pyrrolidinyl)butyl]amino]carbonyl]amino]-4-isothiazolecarboxamide;CP547632;3-(4-Brom-benzyloxy)-benzoesaeure;3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-butyl)-ureido]-isothiazole-4-carboxylic acid amide;3-(4-bromo-benzyloxy)-benzoic acid;3-(4-Bromo-phenoxymethyl)-benzoic acid |
| SMILES: | O=C(NC1=C(C(N)=O)C(OCC2=C(F)C=C(Br)C=C2F)=NS1)NCCCCN3CCCC3 |
| Formula: | C20H24N5O3F2Sbr |
| M.Wt: | 532.40206 |
| Purity: | 99% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Description: | Description of CP-547632: CP-547632 is as a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor (FGF) kinases (IC50 11 and 9 nM, respectively). It is selective relative to epidermal growth factor receptor, platelet-derived growth factor, and other related TKs. It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM. After oral administration of CP-547,632 to mice bearing NIH3T3/H-ras tumors, VEGFR-2 phosphorylation in tumors was inhibited in a dose-dependent fashion (EC50 590 ng/ml). CP-547,632 is a well-tolerated, orally-bioavailable inhibitor presently under clinical investigation For the treatment of human malignancies. For the detailed information about the solubility of CP-547632 in water, the solubility of CP-547632 in DMSO, the solubility of CP-547632 in PBS buffer, the animal experiment（test） of CP-547632,the in vivo,in vitro and clinical trial test of CP-547632,the cell experiment（test） of CP-547632,the IC50, EC50 and Affinity of CP-547632, please contact DC Chemicals. |
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