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| Cas No.: | 19356-17-3 |
| SMILES: | C[C@H](CCCC(C)(O)C)[C@@H]1[C@](CCC/2)(C)[C@](CC1)([H])C2=CC=C(C[C@H]3O)/C(CC3)=C |
| Formula: | C27H46O3 |
| M.Wt: | 418.6523 |
| Purity: | >99% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22 |
| Description: | Calcifediol is a major circulating metabolite of vitamin D3, acting as a competitive inhibitor with an apparent Ki of 3.9 μM, suppresses PTH secretion and mRNA (ED50=2 nM). |
| Target: | Human Endogenous Metabolite |
| In Vitro: | Calcifediol in either liposomes or ethanolic solution has no effect on the release of the proinflammatory cytokine KC from Pseudomonas-infected murine epithelial cells. Treatment of infected, human bronchial 16-HBE cells with Calcifediol liposomes results in a significant reduction in bacterial survival[1]. |
| References: | [1]. Castoldi A, et al. Calcifediol-loaded liposomes for local treatment of pulmonary bacterial infections. Eur J Pharm Biopharm. 2016 Nov 22 |
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