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Carmustine

  Cat. No.:  DC8972   Featured
Chemical Structure
154-93-8
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More than 5000 active chemicals with high quality for research!
Field of application
Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 154-93-8
SMILES: ClCCN(N=O)C(NCCCl)=O
Formula: C5H9Cl2N3O2
M.Wt: 214.05
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Carmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
In Vivo: Carmustine (BCNU; 25 mg/kg, i.p.) causes higher levels of the rhe ratio of liver weight to body weight and plasma conjugated bilirubin, and lower biliary flow, oxidised glutation levels (GSSG) and reduced glutation (GSH)/GSSG values compared with control rats[2].
In Vitro: Carmustine is an antitumor chemotherapeutic agent. Carmustine (8, 80, and 800 µM) decreases N-acetyltransferase (NAT) activities for 2-aminofluorene (AF) and p-aminobenzoic acid (PABA) in rat glial tumor cytosol and intact cells. In rat glial tumor cells, the DNA-AF adduct increases, and carmustine decreases the formation of DNA-AF adduct[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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