Danicopan|ACH-4471|CAS 1903768-17-1|DC Chemicals

Cas No.:	1903768-17-1
Chemical Name:	Danicopan free base
Synonyms:	ACH-4471;ACH4471;ACH-0144471
SMILES:	N(C(CN1C2=C(C=C(C3=CN=C(C)N=C3)C=C2)C(C(C)=O)=N1)=O)1C[C@@H](F)C[C@@H]1C(NC1=NC(Br)=CC=C1)=O
Formula:	C₂₆H₂₃BrFN₇O₃
M.Wt:	580.418
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	Danicopan, a selective and orally active small-molecule factor D inhibitor, inhibits alternative pathway of complement (APC) activity. Danicopan has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].
Target:	Factor D[1]
References:	[1]. https://www.ncbi.nlm.nih.gov/pubmed/28416568

Cat. No.	Product name	Field of application
DC11082	Danicopan (ACH-4471)	Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.
DC11688	Avacopan	Avacopan is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.

Danicopan (ACH-4471)