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Home > Inhibitors & Agonists > Epigenetics > Bromodomain

BAY-850

  Cat. No.:  DC11505   Featured
Chemical Structure
2099142-76-2
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Field of application
BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2099142-76-2
Chemical Name: BAY-850
Synonyms: BAY-850;N-[(2S)-1-[(4-Aminocyclohexyl)amino]-3-(4-cyanophenyl)propan-2-yl]-2-chloro-4-methoxy-5-[5-[[[(1S)-1-(4-methylphenyl)ethyl]amino]methyl]furan-2-yl]benzamide
SMILES: ClC1=CC(=C(C2=CC=C(CN[C@@H](C)C3C=CC(C)=CC=3)O2)C=C1C(N[C@@H](CC1C=CC(C#N)=CC=1)CNC1CCC(CC1)N)=O)OC
Formula: C38H44ClN5O3
M.Wt: 654.240668296814
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM.
In Vitro: BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1].
References: [1]. Fernández-Montalván AE, et al. Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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