CCT-271850|CCT271850;CCT 271850

Cas No.:	1578244-34-4
Chemical Name:	(S)-N8-(3,3-dimethylbutan-2-yl)-N2-(2-methoxy-4-(1-methyl-1H-pyrazol-4-yl)phenyl)pyrido[3,4-d]pyrimidine-2,8-diamine
Synonyms:	CCT271850;CCT 271850
SMILES:	C(NC1=CC=C(C2=CN(C)N=C2)C=C1OC)1=NC=C2C=CN=C(N[C@@H](C(C)(C)C)C)C2=N1
Formula:	C₂₄H₂₉N₇O
M.Wt:	431.544
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM; displays >1,000-fold selectivity over CDK-2, Aurora A/B and PLK1; inhibits HCT116 cells growth with GI50 of 0.16 uM, sensitises selectively MSI+ colon cancer and basal breast cancer cell lines to cell death; active in vivo.

Cat. No.	Product name	Field of application
DC28264	TC-Mps1-12	TC-Mps1-12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor, with an IC50 of 6.4 nM.
DC5087	Mps1-IN-1	Mps1-IN-1 is a highly potent and selectibe Mpsl inhibitor with IC50 of 367 nM; >1000-fold selectivity relative to the 352 member kinase panel with the major exceptions of Alk and Ltk.
DC11677	CCT-271850	A potent, selective, orally bioavailable Mps1 kinase inhibitor with IC50 of 11 nM.
DC11704	CFI-401870	A potent, selective, orally active Mps1 (TTK) inhibitor with IC50 of 3.1 nM.