PD 404182||CAS 72596-74-8|DC Chemicals

Cas No.:	72596-74-8
Chemical Name:	6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine
Synonyms:	PD404182;PD-404182
SMILES:	N=C1SC2=CC=CC=C2C3=NCCCN13
Formula:	C₁₁H₁₁N₃S
M.Wt:	217.29
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro[1][2].

In Vitro:

PD 404182 (20 μM) increases asymmetric dimethylarginine (ADMA) approximately 70% in ECs[1]. PD 404182 (50-100 μM; 18 hours) attenuates endothelial tube formation in virto and does not perturb cell membrane integrity or induces cytotoxicity[1]. PD 404182 inhibits HIV-1 in seminal plasma, with an IC50 of 1 μM[2]. PD 404182 (300 μM;30 minutes) exhibits low toxicity toward several human cell lines , freshly activated PBMCs, primary CD4+ T lymphocytes, macrophages, and dendritic cells, and lactobacilli found in the normal vaginal flora[2]. Cell Viability Assay[1] Cell Line: Human dermal microvascular endothelial cells (ECs) Concentration: 10-300 μM Incubation Time: 24 hours Result: Did not induce cytotoxicity.

COA

MSDS

Cat. No.	Product name	Field of application
DC12012	PD 404182	PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM). Also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). Exhibits antiangiogenic and antiviral activity in vitro. Putative antibiotic against gram-negative bacteria.