N-piperidine Ibrutinib hydrochloride|CAS 2231747-18-3|DC Chemicals

Cas No.:	2231747-18-3
Chemical Name:	N-Piperidine Ibrutinib (hydrochloride)
Synonyms:	N-piperidine Ibrutinib (hydrochloride);N-piperidine Ibrutinib hydrochloride
SMILES:	Cl[H].O(C1C([H])=C([H])C([H])=C([H])C=1[H])C1C([H])=C([H])C(=C([H])C=1[H])C1C2=C(N([H])[H])N=C([H])N=C2N(C2([H])C([H])([H])C([H])([H])N([H])C([H])([H])C2([H])[H])N=1
Formula:	C₂₂H₂₃ClN₆O
M.Wt:	422.9106
Purity:	>98%
Sotrage:	Please store the product under the recommended conditions in the Certificate of Analysis.

Cat. No.	Product name	Field of application
DC40447	N-piperidine Ibrutinib hydrochloride	N-piperidine Ibrutinib hydrochloride (Compound 1) is a reversible Ibrutinib derivative. N-piperidine Ibrutinib hydrochloride is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively. N-piperidine Ibrutinib hydrochloride can be used as a BTK ligand in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
DC28073	CNX-500	CNX-500 is a probe consisting of a covalent Btk inhibitor (CC-292) chemically linked to biotin. CNX-500 retains inhibitory activity against Btk (IC50 of 0.5 nM) and the ability to form a covalent bond with Btk. CNX-500 has low inhibitory effects on kinase epidermal growth factor receptor, and upstream Src-family kinases including Syk and Lyn.