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ML251

  Cat. No.:  DC60028   Featured
Chemical Structure
1486482-16-9
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More than 5000 active chemicals with high quality for research!
Field of application
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1486482-16-9
Chemical Name: ML251
Synonyms: 2-(3,4-Dichlorophenyl)-N-[4-(1,2-oxazol-3-ylsulfamoyl)phenyl]acetamide;ML251;2-(3,4-Dichlorophenyl)-N-(4-(N-(isoxazol-3-yl)sulfamoyl)phenyl)acetamide;2-(3,4-dichlorophenyl)-n-(4-(1,2-oxazol-3-ylsulfamoyl)phenyl)acetamide;BDBM50446100;ML251?;2-(3,4-Dichlorophenyl)-N-4-(1,2-oxazol-3-ylsulfamoyl)phenylacetamide
SMILES: ClC1=C(C([H])=C([H])C(=C1[H])C([H])([H])C(N([H])C1C([H])=C([H])C(=C([H])C=1[H])S(N([H])C1C([H])=C([H])ON=1)(=O)=O)=O)Cl
Formula: C17H13Cl2N3O4S
M.Wt: 426.2738
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].
Target: IC50: 0.37 μM (T. brucei PFK)[1]. IC50: 0.13 μM (T. cruzi PFK)[1]
In Vitro: ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1]. Cell Cytotoxicity Assay[1] Cell Line: T. brucei Concentration: 0~33.3 μg/mL Incubation Time: Result: Dose-dependent reduction of cell viability.
References: [1]. Brimacombe KR, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013;5(1):12-17.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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