JNJ-63576253 HCl|cas 2110428-64-1|DC Chemicals

Cas No.:	2110428-64-1
Chemical Name:	JNJ-63576253 HCl
Synonyms:	JNJ-63576253;s9900;JNJ-63576253 HCl
SMILES:	Cl[H].S=C1N(C2C([H])=NC(C#N)=C(C(F)(F)F)C=2[H])C(C2(C([H])([H])C([H])([H])C2([H])[H])N1C1=C([H])N=C(C([H])=C1[H])OC1([H])C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H])=O
Formula:	C₂₃H₂₂ClF₃N₆O₂S
M.Wt:	538.9730
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC60203	JNJ-63576253 HCl	JNJ63576253, also known as TRC253, is a potent and orally active androgen receptor antagonist. TRC253 specifically binds to both wild-type and certain mutant forms of AR, thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot translocate to the nucleus.
DC60202	YUN35454	YUN35454, also known as LMPTP INHIBITOR 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A. LMPTP is a key promoter of insulin resistance and that LMPTP inhibitors would be beneficial for treating type 2 diabetes. YUN35454 was first reported in Nature Chemical Biology (2017), 13(6), 624-632.
DCAPI1594	Oseltamivir phosphate	OSELTAMIVIR is an active (orally) inhibitor of the influenze virus neuraminidase and converted to the active acid metabolite in vivo.
DCH-057	Trigonelline	>98%,Standard References
DCW-004	Citric acid	Citric acid is a natural preservative and food tartness enhancer. Citric acid induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid causes renal toxicity in mice.
DCB-029	Anemoside B4	Pulchinenoside B4 is a triterpenoid glycoside that inhibits cisplatin-induced apoptosis, increases in reactive oxygen species (ROS) production, and decreases in superoxide dismutase (SOD) and catalase activities. Pulchinenoside B4 also prevents increases in plasma blood urea nitrogen (BUN) and creatinine levels -- markers of kidney injury.
DCG-043	Triolein	Triolein is a symmetric triacylglycerol that reduces upregulation of MMP-1 and has strong antioxidant and anti-inflammatory activities.
DCG-004	Glycyrrhizic acid	>98%,Standard References
DCF-003	Lycopene	>98%,Standard References
DCT-004	Crustecdysone	Crustecdysone (20-Hydroxyecdysone) is a naturally occurring ecdysteroid hormone isolated from Serratula coronata which controls the ecdysis (moulting) and metamorphosis of arthropods, it inhibits caspase activity and induces autophagy via the 20E nuclear receptor complex, EcR-USP. Crustecdysone exhibits regulatory or protective roles in the cardiovascular system. Crustecdysone is an active metabolite of Ecdysone (HY-N0179).