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HM03

  Cat. No.:  DC39046   Featured
Chemical Structure
500565-15-1
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More than 5000 active chemicals with high quality for research!
Field of application
HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 500565-15-1
Chemical Name: 6-chloro-9-({4-hydroxy-3-[(4-methylpiperazin-1-yl)methyl]phenyl}amino)-2-methoxyacridinium chloride
Synonyms: HM03 ;HM-03 ;HM 03
SMILES: OC1=CC=C(NC2=C(C=C(OC)C=C3)C3=NC4=CC(Cl)=CC=C42)C=C1CN5CCN(C)CC5
Formula: C26H27ClN4O2
M.Wt: 462.97
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044‐3050.
Description: HM03 is a potent and selective HSPA5 (Heat shock 70kDa protein 5, also known as Bip, Grp78) inhibitor. HM03 has anticancer activity[1].
Target: HSPA5
In Vitro: HM03 (0.1-50 μM; 72 hours) exhibits over 50% inhibition at 25 µM concentration in HCT116 cells[1]. HM03 forms more binding interactions with HSPA5 and HSPA9 than with the other HSP70 proteins[1]. HM03 exhibits promising inhibition activities from cancer cell viability and tumor inhibition assays[1]. Cell Viability Assay[1] Cell Line: HCT116 cells Concentration: 0.1, 1, 10, 25, 50 μM Incubation Time: 72 hours Result: Exhibited prominent inhibition effect (18% survival at 25 µM).
References: [1]. Huang M, et al. Structure-based design of HSPA5 inhibitors: from peptide to small molecule inhibitors. Bioorg Med Chem Lett. 2013;23(10):3044‐3050.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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