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ML347

  Cat. No.:  DC7587   Featured
Chemical Structure
1062368-49-3
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More than 5000 active chemicals with high quality for research!
Field of application
ML347 is a selective BMP receptor inhibitor with IC50 of 32 nM for ALK2, >300-fold selectivity over ALK3. Also inhibits ALK1 activity with IC50 of 46 nM
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1062368-49-3
Chemical Name: Quinoline, 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]-
SMILES: N1C2C(=C(C3=C4N(N=C3)C=C(C3=CC=C(OC)C=C3)C=N4)C=CC=2)C=CC=1
Formula: C22H16N4O
M.Wt: 352.39
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.ML347 has IC50’s of 46 and 32 nM, respectively, against ALK1 and ALK2; however, the IC50 against ALK3 is 10,800 nM, >300-fold selective over ALK3. ML347 is completely inactive against allthe other kinases tested (with weak activity against ALK6, 9830 nM and KDR (VEGFR2)19,700 nM). ML347 is potent in the BMP4 cell assay (152 nM).
Target: ALK1/ALK2
References: [1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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