NT1-O12B|Ionizable Lipid for LNP

Cas No.:	2739805-63-9
Chemical Name:	NT1-O12B
Synonyms:	NT1O12B，， NT1 O12B
SMILES:	CCCCCCCCSSCCOC(CCN(CCC(OCCSSCCCCCCCC)=O)CCC1=CNC2=C1C=CC=C2)=O
Formula:	C₃₆H₆₀N₂O₄S₄
M.Wt:	713.13
Purity:	ELSD-HPLC>95%
Sotrage:	1 year -20°C

Cat. No.	Product name	Field of application
DC82025	306-O12B-3	306-O12B-3 is an ionizable lipidoid with cationic properties, commonly used in lipid nanoparticle (LNP) formulations for antisense oligonucleotide (ASO) delivery. When administered intravenously in mice, LNPs incorporating 306-O12B-3 exhibit liver-specific accumulation. Studies show that ASO-loaded LNPs containing 306-O12B-3 effectively silence hepatic PCSK9 expression by targeting the proprotein convertase subtilisin/kexin type 9 gene. Additionally, when combined with the cationic lipidoid NT1-O14B (Item No. 37095), these LNPs can deliver tau-targeting ASOs to the brain, reducing tau protein levels in mice.
DC60212	NT1-O14B	NT1-O14B is a tryptamine-containing cationic lipidoid.1 It has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs). Intravenous administration of LNPs containing NT1-O14B and encapsulating antisense nucleotides against tau decreases tau brain levels in mice.
DC41043	NT1-O12B	NT1-O12B, an endogenous chemical and a neurotransmitter-derived lipidoid (NT-lipidoid), is an effective carrier for enhanced brain delivery of several blood-brain barrier (BBB)-impermeable cargos. Doping NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) gives the LNPs the ability to cross the BBB. NT-lipidoids formulation not only facilitate cargo crossing of the BBB, but also delivery of the cargo into neuronal cells for functional gene silencing or gene recombination.