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| Cas No.: | 252920-94-8 |
| Chemical Name: | [1,1'-Biphenyl]-3-carboxylicacid, 3'-[[2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]- |
| Synonyms: | GW427353,GW-427353,GW 427353 |
| SMILES: | O=C(O)C1C=CC=C(C2C=C(NCCNC[C@H](O)C3C=C(Cl)C=CC=3)C=CC=2)C=1 |
| Formula: | C23H23ClN2O3 |
| M.Wt: | 410.89 |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. [2]. Andersson KE, et al. Sele |
| Description: | Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1]. |
| In Vivo: | Solabegron (GW427353) at 3 mg/kg i.v. evokes an increase in micturition volume threshold that prevented the acetic acid-evoked decreases in dogs. The low dose (1 mg/kg) shows no significant activity[1]. Animal Model: Adult female beagle dogs (6-10 kg)[1]. Dosage: 1, 3 mg/kg. Administration: I.V. once. Result: Dosage of 3 mg/kg evoked an increase in micturition volume threshold. |
MSDS
COA
| LOT NO. | DOWNLOAD |
| 2018-0101 |
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| 2018-0101 |
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