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TMN355

  Cat. No.:  DC39010   Featured
Chemical Structure
1186372-20-2
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More than 5000 active chemicals with high quality for research!
Field of application
TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1186372-20-2
Chemical Name: 2-Chloro-N-[(9H-fluoren-9-ylamino)carbonyl]-6-fluorobenzamide
Synonyms: TMN355 ;TMN-355 ;TMN 355
SMILES: O=C(NC(=O)C1=C(Cl)C=CC=C1F)NC2C3C(=CC=CC=3)C4=C2C=CC=C4
Formula: C21H14N2O2FCl
M.Wt: 380.79946
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: [1]. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
Description: TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1].
Target: cyclophilin A[1]
In Vitro: TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: THP cell lines Concentration: 0.5, 1, 2.5, 5 and 10 μM Incubation Time: 3, 6 and 9 hours Result: Resulted in 75.9% reduction of cyclophilin A protein expression.
References: [1]. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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