USP7-USP47 inhibitor|cas 1247825-37-1|DC Chemicals|Price|Buy

Cas No.:	1247825-37-1
Chemical Name:	2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-
Synonyms:	2-Thiophenecarboxamide, 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-
SMILES:	ClC1=CN=CC(Cl)=C1SC2=C(C#N)C=C(C(NC3=CC=C(S(C)(=O)=O)C=C3)=O)S2
Formula:	C₁₈H₁₁Cl₂N₃O₃S₃
M.Wt:	484.4
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47). IC50 value: 0.42/1.0 uM (USP7/47) Target: USP7/USP47 USP7/USP47 inhibitor(compound 14) is a selective USP7 (EC50= 0.42 μM)/USP47 (EC50= 1.0 μM) inhibitor but does not inhibit caspase 3, calpain 1, 20S proteasome, and a panel of representative USPs (USP2, USP5, USP8, USP21, and USP28; EC50 > 31.6 μM Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47. compound 14 exhibits enhanced potency against HCT-116 cells. treatment of cells with compound 14 resulted in an increase in p53 and an appreciable induction of p21 protein over the DMSO control. Thus, compound 14 penetrated the cells and modulated p53 and p21 as expected For a USP7 inhibitor .For the detailed information of USP7-USP47 inhibitor, the solubility of USP7-USP47 inhibitor in water, the solubility of USP7-USP47 inhibitor in DMSO, the solubility of USP7-USP47 inhibitor in PBS buffer, the animal experiment (test) of USP7-USP47 inhibitor, the cell expriment (test) of USP7-USP47 inhibitor, the in vivo, in vitro and clinical trial test of USP7-USP47 inhibitor, the EC50, IC50,and Affinity of USP7-USP47 inhibitor, Please contact DC Chemicals.

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2018-0101

Cat. No.	Product name	Field of application
DC47696	Vialinin A	Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research.
DC46636	USP30 inhibitor 18	USP30 inhibitor 18 is a selective USP30 inhibitor with an IC50 of 0.02 μM. USP30 inhibitor 18 increases protein ubiquitination and accelerates mitophagy.
DC46374	USP30 inhibitor 11	USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.
DC45368	LCAHA	LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a.
DC28552	USP7-IN-6	USP7-IN-6 is a potent ubiquitin specific protease 7 (USP7) inhibitor, extracted from patent WO2017212010A1, example 25, has an IC50 of 6.8 nM.
DC28551	USP7-IN-5	USP7-IN-5 is a potent ubiquitin specific protease 7 (USP7) inhibitor extracted from patent WO2017212012A1, example 40, has an IC50 of 49.9 nM.
DC11876	XL 188	XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.
DC7525	USP7-USP47 inhibitor	USP7/USP47 inhibitor is a potent and dual inhibitor of USP7/USP47 with IC50s of 0.42 uM(USP7) and 1.0 uM(USP47).
DC11509	USP25 and 28 inhibitor AZ-2	USP25 and 28 inhibitor AZ-2 is a potent, selective, dual USP25/28 inhibitor with IC50 of 0.9/0.9 uM, respectively.
DC10298	Ubiquitin Isopeptidase Inhibitor I, G5	Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303) is an apoptosome-independent caspase and apoptosis activator with IC50 values of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.