VX-680 (MK-0457,Tozasertib)

  Cat. No.:  DC3106   Featured
VX-680 (MK-0457,Tozasertib)
Chemical Structure
639089-54-6
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Field of application
VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.
Cas No.: 639089-54-6
Chemical Name: N-(4-(4-(5-methyl-1H-pyrazol-3-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide
Synonyms: VX680,MK0457,VX 680 (MK 0457,Tozasertib)
SMILES: CC1=CC(=NN1)NC2=NC(=NC(=C2)N3CCN(CC3)C)SC4=CC=C(C=C4)NC(=O)C5CC5
Formula: C23H28N8Os
M.Wt: 464.59
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:
Description: Tozasertib lactate is the lactate salt of tozasertib, a synthetic, small-molecule Aurora kinase inhibitor with potential antitumor activity. Tozasertib binds to and inhibits Aurora kinases (AKs), thereby inducing apoptosis in tumor cells in which AKs are overexpressed. AKs, a family of serine-threonine kinases, are essential For mitotic progression, spindle Formation, centrosome maturation, chromosomal segregation, and cytokinesis. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of VX-680 (MK-0457, Tozasertib) in water, the solubility of VX-680 (MK-0457, Tozasertib) in DMSO, the solubility of VX-680 (MK-0457, Tozasertib) in PBS buffer, the animal experiment(test) of VX-680 (MK-0457, Tozasertib),the in vivo,in vitro and clinical trial test of VX-680 (MK-0457, Tozasertib),the cell experiment(test) of VX-680 (MK-0457, Tozasertib),the IC50, EC50 and Affinity of VX-680 (MK-0457, Tozasertib), please contact DC Chemicals.
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MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC3106 VX-680 (MK-0457,Tozasertib) VX-680 (MK-0457, Tozasertib) is a pan-Aurora inhibitor of Aurora A, Aurora B and Aurora C with Kiapp of 0.6 nM, 18 nM and 4.6 nM, respectively.
DC4125 PHA-739358 (danusertib) Danusertib (PHA-739358) is an Aurora inhibitor for Aurora A/B/C, Bcr-Abl, c-RET and FGFR with IC50 of 13 nM/79 nM/61 nM, 25 nM, 31 nM and 47 nM, respectively.
DC7070 AT9283 AT9283 is a small molecule a multi-targeted inhibitor with of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), Jak2 and Jak3, aurora A and B, respectively.
DC9366 AMG 900 AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM; >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2.