ARN23746|ARN23746(IAMA-6)|DC Chemicals

Cas No.:	2497525-96-7
Chemical Name:	ARN23746
Synonyms:	ARN-23746
SMILES:	O=C(O)C1=CC(S(=O)(N(C)C)=O)=C(NCCCCCCCC(F)(F)F)C=C1
Formula:	C₁₇H₂₅F₃N₂O₄S
M.Wt:	410.452
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	1. Savardi A, et al. Chem. 2020 Aug 6;6(8):2073-2096. 2. Borgogno M, et al. J Med Chem. 2021 Jul 22;64(14):10203-10229

Description:

ARN 23746 (ARN-23746) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.ARN23746 did not show significant NKCC2 inhibition and KCC2 inhibition at 10 uM.ARN23746 selectively blocks NKCC1 in a human cell line and restore the physiological [Cl−]i in murine DS neurons in culture, has excellent solubility and metabolic stability, and displays no issues with off-target activity in vitro.ARN23746 demonstrated in vivo efficacy in rescuing cognitive impairment in a DS mouse model and social deficits and repetitive behaviors in an autism mouse model.

References:

1. Savardi A, et al. Chem. 2020 Aug 6;6(8):2073-2096. 2. Borgogno M, et al. J Med Chem. 2021 Jul 22;64(14):10203-10229

Cat. No.	Product name	Field of application
DC70203	ARN23746(IAMA-6)	ARN 23746 (ARN-23746) is a potent, selective inhibitor of Na+-K+-Cl- importer NKCC1, shows NKCC1 inhibition 31.8% at 10 uM, and 95.2% at 100 uM in the Cl− influx assay on NKCC1-transfected HEK293 cells.ARN23746 did not show significant NKCC2 inhibition and KCC2 inhibition at 10 uM.ARN23746 selectively blocks NKCC1 in a human cell line and restore the physiological [Cl−]i in murine DS neurons in culture, has excellent solubility and metabolic stability, and displays no issues with off-target activity in vitro.ARN23746 demonstrated in vivo efficacy in rescuing cognitive impairment in a DS mouse model and social deficits and repetitive behaviors in an autism mouse model.