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DC8040 | STAT3 Inhibitor XVIII, BP-1-102 Featured |
BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor.BP-1-102 could enhance the transfection efficiency to 2-fold to 5-fold of Lipofectamine 3000 and LNP, all of which are currently approved for clinical use in the treatment of the most common malignant tumors.
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DC74445 | FL-1607 Featured |
FL-1607, a novel Fam20C inhibitor, has shown remarkable anti-proliferative effects in triple-negative breast cancer (TNBC) cells. This compound induces apoptosis and significantly reduces the migration ability of MDA-MB-468 cells, underscoring its potential as a promising therapeutic agent for TNBC treatment.
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DC70591 | mCLB073 Featured |
mCLB073 is an advanced, orally active small molecule agonist specifically designed to target Mtb adenylyl cyclase Rv1625c. As an optimized derivative of V-59, it demonstrates significantly enhanced potency and efficacy for in vivo applications. In cholesterol-based media, mCLB073 shows a remarkable 17-fold increase in activity against Mtb compared to its predecessor, V-59, while retaining favorable pharmacokinetic characteristics and a strong safety profile. In preclinical studies, oral administration of mCLB073 at 30 mg/kg led to a substantial reduction in Mtb colony-forming units (CFUs) in the lungs of mice, accompanied by a 45% decrease in lung pathology severity. These findings highlight its potential as a promising therapeutic candidate for tuberculosis treatment.
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DC71716 | Obeldesivir (GS-5245, ATV006) Featured |
ATV006 is a potent, orally active antiviral agent and ester prodrugs of GS-441524. ATV006 inhibits the replication of SARS-CoV-2 and its variants. ATV006 can be used for SARS-CoV-2 research.
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A480 | Abbv-011 Biosimilar(Anti-SEZ6 Reference Antibody) Featured |
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A479 | Sanofi patent anti-PAI-1 Biosimilar(Anti-SERPINE1 Reference Antibody) Featured |
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A478 | Pepinemab Biosimilar(Anti-SEMA4D / CD100 Reference Antibody ) Featured |
Pepinemab (VX 15/2503) is a human monoclonal antibody against SEMA4D, a signalling protein 4D (SEMA4D), also known as CD100, which is a regulator of neuronal development and plays a role in a variety of cellular processes. Pepinemab can be used in the study of various neurodegenerative diseases such as Alzheimer's disease by blocking the activity of SEMA4D.
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A477 | Duke anti-NAv1.7 Biosimilar(Anti-SCN9a / Nav1.7 Reference Antibody) Featured |
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A476 | Wuhan U. patent anti-Nav1.9 Biosimilar(Anti-SCN11a / Nav1.9 Reference Antibody) Featured |
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A475 | LOP628 Biosimilar(Anti-SCFR / c-Kit / CD117 Reference Antibody) Featured |
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A474 | CDX-0158 Biosimilar(Anti-SCFR / c-Kit / CD117 Reference Antibody) Featured |
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A473 | LK-1 Biosimilar(Anti-S100A4 Reference Antibody) Featured |
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A472 | NG-101 Biosimilar(Anti-RTN4 / NOGO Reference Antibody) Featured |
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A471 | Atinumab Biosimilar(Anti-RTN4 / NOGO Reference Antibody) Featured |
Atinumab (6A3-IgG4) is an antibody. Teropavimab can be used for the research of spinal cord injury (SCI).
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A470 | Ozanezumab Biosimilar(Anti-RTN4 / NOGO Reference Antibody) Featured |
Ozanezumab (GSK1223249) is an anti-Nogo-A (neurite outgrowth inhibitor A) monoclonal antibody. Ozanezumab can be used in amyotrophic lateral sclerosis (ALS) and multiple sclerosis research.
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A469 | Motavizumab Biosimilar(Anti-RSV-F Reference Antibody) Featured |
Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research.
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A468 | Palivizumab Biosimilar(Anti-RSV-F Reference Antibody) Featured |
Palivizumab (MEDI 493) is a humanized monoclonal antibody against respiratory syncytial virus (RSV). Palivizumab can bind to RSV F protein with a Kd value of 1.4 nM. Palivizumab can prevent respiratory syncytial virus infection in cotton mice.
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A467 | Rosmantuzumab Biosimilar(Anti-RSPO3 Reference Antibody) Featured |
Rosmantuzumab (OMP-131R10) is an anti-R-spondin 3 (RSPO3) humanized monoclonal antibody. Rosmantuzumab can be used for the research of advanced telapsed and refractory solid tumors.
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A466 | Oncomed patent anti-RSPO1 Biosimilar(Anti-RSPO1 Reference Antibody ) Featured |
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A465 | Ozuriftamab Biosimilar(Anti-ROR2 Reference Antibody) Featured |
Ozuriftamab is a naked human IgG1 kappa antibody of receptor tyrosine kinase-like orphan receptor 2 ROR2, can be used to synthesis ADC.
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A464 | Zilovertamab Biosimilar(Anti-ROR1 Reference Antibody) Featured |
Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.
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A463 | Asclepius Technology patent anti-Robo1 CAR Biosimilar(Anti-ROBO1 Reference Antibody) Featured |
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A462 | LFB Anti-RhD Biosimilar(Anti-RHD / CD240d Reference Antibody) Featured |
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A461 | Roledumab Biosimilar(Anti-RHD / CD240d Reference Antibody) Featured |
Roledumab (LFB-R593) is a human IgG1-κ antibody targeting RHD/CD240D. Roledumab is expressed by YB2/0 rat hybridoma cells.
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A460 | DISC-0974 Biosimilar(Anti-RGMC / HFE2 Reference Antibody) Featured |
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A459 | Elezanumab Biosimilar(Anti-RGMA Reference Antibody) Featured |
Elezanumab (ABT-555; AE12-1Y-QL) is a human monoclonal antibody that selectively targets repulsive guidance molecule A (RGMa). Elezanumab potently inhibited RGMa mediated BMP signalling via the SMAD1/5/8 pathway, with an IC50 around 97 pM. Elezanumab promotes neuroregeneration and neuroprotection in neuronal injury and demyelination models binds N-terminal RGMa, blocks BMP signaling and lacks RGMc cross-reactivity. elezanumab has neuroregenerative and neuroprotective activities without impact on iron metabolism.
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A458 | 19G9 Biosimilar(Anti-RG1 Reference Antibody) Featured |
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A457 | Medella patent anti-RAMP-3 Biosimilar(Anti-RAMP3 Reference Antibody) Featured |
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A456 | Rafivirumab Biosimilar(Anti-Rabies virus GP Reference Antibody) Featured |
Rafivirumab (CR57) is an anti-rabies virus monoclonal antibody for the prophylaxis of rabies. Rafivirumab has neutralizing potency against a broad spectrum of RABV variants. Rafivirumab can be used for research of cocktails.
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A455 | Foravirumab Biosimilar(Anti-Rabies virus GP Reference Antibody) Featured |
Foravirumab (CR4098) is a monoclonal antibody against rabies virus glycoprotein antigenic site III.
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