MCT4-IN-1|CAS 2445185-57-7|DC Chemicals

Cas No.:	2445185-57-7
Chemical Name:	MSC-4381
Synonyms:	2-Pyridinecarboxylic acid, 5-[2-[5-chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-;MSC-4381;compound 18n [PMID: 34382802];BDBM50610836;HY-132301;CHEMBL4802043;AKOS040756056;GTPL11735;DA-75373;MS-29926;EX-A7017;5-[2-[5-chloro-2-[(5-ethoxyquinolin-8-yl)sulfonylamino]phenyl]ethynyl]-4-methoxypyridine-2-carboxylic acid;CS-0200365;2445185-57-7;F82982;MCT4-IN-1;SCHEMBL22116621
SMILES:	O(C1=C2C(N=CC=C2)=C(S(=O)(=O)NC2C=CC(=CC=2C#CC2C(OC)=CC(=NC=2)C(O)=O)Cl)C=C1)CC
Formula:	C₂₆H₂₀ClN₃O₆S
M.Wt:	537.97
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC39028	BIA	BIA is a potential TMBIM6 antagonist, prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, and also regulates TMBIM6-leaky Ca2+, further suppressing tumor formation and progression in cancer xenograft models.It is a potential anticancer agent that prevents the binding between mTORC2 and TMBIM6.
DC47562	VB124	VB-124 is a potent and selective MCT4 inhibitor. VB124 might redirect glycolytic carbon flux into mitochondrial pyruvate oxidation. VB 124 bolcks lactate import (IC50=8.6nM), and export (IC50=19nM) in MDA-MB-231 cells that are engineers to express MCT4 as the only major plasma membrane lactate transporter.
DC46528	MCT4-IN-1	MCT4-IN-1 is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC50 of 77 nM and a Ki of 11 nM. MCT4-IN-1 targets to the cytosolic domain of MCT4. MCT4-IN-1 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MCT4-IN-1 has the potential for MCT4 transporter inhibition research.