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Inhibitors & Agonists

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Cat. No. Product Name Field of Application Chemical Structure
DC10020 Fluticasone furoate Featured
Fluticasone furoate is a synthetic trifluorinated corticosteroid with potent anti-inflammatory activity.
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DC26027 FMF-04-159-2 Featured
FMF-04-159-2 is a covalent CDK14 inhibitor. FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively.
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DC7618 NI-(S)-BPB-GLY Featured
For the detailed information of NI-(S)-BPB-GLY, the solubility of NI-(S)-BPB-GLY in water, the solubility of NI-(S)-BPB-GLY in DMSO, the solubility of NI-(S)-BPB-GLY in PBS buffer, the animal experiment (test) of NI-(S)-BPB-GLY, the cell expriment (test) of NI-(S)-BPB-GLY, the in vivo, in vitro and clinical trial test of NI-(S)-BPB-GLY, the EC50, IC50,and Affinity of NI-(S)-BPB-GLY, Please contact DC Chemicals..
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DC22285 praeruptorin B Featured
For the detailed information of praeruptorin B, the solubility of praeruptorin B in water, the solubility of praeruptorin B in DMSO, the solubility of praeruptorin B in PBS buffer, the animal experiment(test) (test) of praeruptorin B, the cell expriment (test) of praeruptorin B, the in vivo, in vitro and clinical trial test of praeruptorin B, the EC50, IC50,and Affinity of praeruptorin B,, please contact DC Chemicals..
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DC7507 HIV-1 integrase inhibitor 8 Featured
HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1].
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DC10510 FPH1 (BRD-6125) Featured
FPH1 (BRD-6125) is a small molecule, which promotes expansion of iPS-derived hepatocytes.
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DC23050 fraxinellone Featured
Fraxinellone is a selective blocker of voltage-dependent Ca2+ channel, which possesses antimicrobial, anti-inflammatory, neuroprotective and vasorelaxing activities.
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DC20272 FT113 Featured
FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme.
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DC11394 Fulacimstat(BAY 1142524) Featured
Fulacimstat(BAY 1142524) is a small molecule chymase inhibitor.
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DCAPI1020 Fumalic acid (Ferulic acid) Featured
Fumalic acid (Ferulic acid)
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DC10814 G-15 Featured
G-15 is a cell-permeable non-steroidal antagonist of GPER (Ki = 20 nM).
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DC10501 G1T28(Trilaciclib) Featured
G1T28(Trilaciclib) is a potential first-in-class, short-acting IV CDK4/6 inhibitor being developed to preserve hematopoietic stem cells and enhance immune system function during chemotherapy.
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DC10816 G-36 Featured
G-36 is a cell-permeable non-steroidal antagonist of GPER, inhibiting activation by either 17β-estradiol or the GPER-selective agonist G-1(IC50 = 112 and 165 nM, respectively).
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DC10133 Gambogic Acid Featured
Gambogic Acid activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM, respectively.
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DC10896 GCN2-IN-1 Featured
GCN2-IN-1 is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with IC50s of <0.3 μM in the enzyme and cell assay.
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DC10485 GDC0575(ARRY-575,RG7441) Featured
GDC0575(ARRY-575,RG7441)is a small molecule inhibitor of cell cycle checkpoint kinase 1 (Chk1), with potential chemosensitization activity.
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DC22324 GDP366 Featured
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells.
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DC2092 Genistein Featured
Genistein is a highly specific inhibitor of protein tyrosine kinase (PTK).
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DC7417 Genz-123346 Featured
Genz-123346 free base is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1; IC50 for GM1 inhibition is 14 nM.
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DC10490 GIBH-130 Featured
GIBH-130 is a novel inhibitor of neuroinflammation effective in Alzheimer’s disease models.
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DC10081 GJ103 Featured
GJ103 is an active analog of the read-through compound GJ072.
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DC8375 GLPG0634 analogue Featured
GLPG0634 (analog) is a pan JAK inhibitor with IC50s of 50-200 nM for JAK1/JAK2/JAK3; more information can be found in the reference patents.
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DC10753 GLPG-1837(ABBV-974) Featured
GLPG-1837(ABBV-974) is a novel cystic fibrosis transmembrane conductance regulator CFTR potentiator.
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DC10003 PF-06291874(glucagon receptor antagonists-4) Featured
glucagon receptor antagonists-4 is a highly potent glucagon receptor antagonist.
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DC11009 GLX351322 Featured
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.
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DC5133 SNX-2112 (PF-04928473) Featured
SNX-2112 selectively binds to the ATP pocket of HSP90α and HSP90β with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG.
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DC23140 AF38469 Featured
AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM, shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin
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DC22906 Lumateperone Featured
Lumateperone (ITI-007) is a potent 5-HT2A antagonist (Ki=0.54 nM), postsynaptic D2 antagonist(Ki=32 nM), and SERT blocker (Ki= 61 nM).
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DC7460 Masitinib Featured
Masitinib is a broad coronavirus 3CL inhibitor that effectively blocks replication of SARS-CoV-2. Science 20 Jul 2021: eabg5827 DOI: 10.1126/science.abg5827
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DC24072 LY-2584702 free base Featured
LY2584702 is a potent, selective, ATP-competitive inhibitor of P70 S6 kinase-1 (p70S6K1) with IC50 of 4 nM.
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