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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC8656 Tiamulin fumarate
Tiamulin is a diterpenic veterinary drug widely used in swine for the control of infectious diseases, including swine dysentery and enzootic pneumonia.
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DC23984 Thyroxine sulfate
Thyroxine sulfate (T4) is a major Thyroid hormone metabolite secreted by follicular cells of the Thyroid gland, T4 is involved in controlling the rate of metabolic processes in the body and influencing physical development, a prohormone and a reservoir fo
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DC24135 THS-044
THS-044 is a low micromolar HIF2α PAS-B binding compound (Kd=2 uM).
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DC23429 THRX-198321
THRX-198321 is a bifunctional mAChR antagonist and β2-adrenoceptor agonist (MABA) with pKi of 9.69/10.05 for M1/M2 respectively, pEC50 of 9.25 for β2AR.
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DC12573 THIQ40
THIQ 40 (THIQ40) is a potent, orally available ERα antagonist and selective estrogen receptor degrader (SERD) with IC50 of 17 nM (ERα binding) and 30 nM (ERα transcription), IC50 of 0.9 nM (ERα degradation).
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DC11362 Thiothixene
Thiothixene is a typical antipsychotic.1 It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis = 0.417, 338, 186.2, and 363.1 nM, respectively).
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DC12363 Thionin acetate (Thionine acetate)
Thionin (acetate) is a metachromic cationic histology dye used in biological staining widely.
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DC8673 Thifluzamide
Thifluzamide is a powerful and effective fungicide. When used safely and correctly it can be effective on rice and other crops because of improved water dispersal techniques. Thifluzamide is highly active against Basidiomycete fungi, in particular Rhizoct
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DC20173 Acefylline;Theophyllineacetic acid; Theophylline-7-acetic acid
Theophylline-7-acetic acid (Acefylline), acting as an adenosine receptor antagonist, is a stimulant drug of the xanthine chemical class.
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DC22541 R-80123
The Z-isomer of R 79595, a highly selective PDE inhibitor, 10-fold more potent than R 79595..
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DC22593 KPT-8602 Z-isomer
The Z-isomer of Eltanexor (KPT-8602), which is a second-generation SINE with markedly reduced brain penetration compared to selinexor..
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DC11492 GMX-1777 chloride
The water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.
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DC20816 BMS 830216
The the phosphate ester prodrug of BMS 819881, a potent, selective melanin concentrating hormone receptor 1 (MCHR1) inhibitor with Ki of 10.4 nM.
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DC9377 6-FAM
The single isomer, 6-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid.
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DC22480 5-FAM
The single isomer, 5-FAM, contains a carboxylic acid that can be used to react with primary amines via carbodiimide activation of the carboxylic acid. Fluorescein is the most common fluorescent derivatization reagent for labeling biomolecules. In addition
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DC23866 LOXO-195 RS-isomer
The RS-isomer of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively..
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DC23999 (R)-Oxiracetam
the R-enantiomer of the nootropic drug oxiracetam (ISF 2522), which is a nootropic drug of the racetam family and stimulant..
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DC22558 Pemafibrate racemate
The racemate of Pemafibrate, which is a highly potent, specific PPARα agonist with EC50 of 1 nM..
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DC23865 LOXO-195 R racemate
The R racemate of LOXO-195, a potent, selective, next-generation Trk tyrosine kinase inhibitor with IC50 of 0.6 nM and <2.5 nM for WT TrkA and WT TrKC, respectively..
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DC24133 Bay 65-1942 R form
The R form of Bay 65-1942. which is a potent, selective, ATP-competitive inhibitor of IKKβ kinase with Ki of 2 nM..
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DC24174 Refametinib R enantiomer
The R enantiomer of Refametinib, a potent, non–ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively..
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DC22456 GLPG-0492 R enantiomer
The R enantiomer of GLPG-0492, a non-steroidal selective androgen receptor modulator (SARM) for treatment for Duchenne muscular dystrophy (DMD).
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DC23989 TG 100801 hydrochloride
The prodrug of TG 100572, a potent, dual receptor tyrosine kinase/Src kinase inhibitor with IC50 of 2-16 nM for VEGFR, FGFR and PDGFR, 0.1-5 nM for Src family.
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DC23955 PF-04929113 Mesylate
The prodrug of PF-04928473 (SNX-2112), a potent, orally bioavailable HSP90 inhibitor.
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DC25073 Cidofovir dihydrate
The prodrug of cidofovir diphosphate that inhibits cytomegalovirus (CMV) viral replication by selectively inhibiting viral DNA polymerases.
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DC23007 AUDA-BE
The prodrug of AUDA, a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 50 nM and 100 nM for mouse sEH and human sEH, respectively.
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DC21524 Pomstafib-2
The pivaloyloxymethyl ester prodrug of Stafib-2, which is a potent, selective STAT5b inhibitor with Ki of 9 nM.
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DC21061 GPA 512
The orally bioavailable prodrug of Galiellalactone, a direct inhibitor of STAT3, prevents the transcription of STAT3 regulated genes.
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DC21777 Candoxatril
The orally active prodrug of candoxatrilat (UK-73967), potent neutral endopeptidase EC 3.4.24.11 (atriopeptidase) inhibitor..
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DC22687 (-)-U-50488 hydrochloride
The more active enantiomer of (±)-U-50488, a potent, selective kappa-opioid receptor agonist with no μ-opioid antagonist effects.
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