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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC21554 AS 703569
Cenisertib (AS 703569;R763) is a novel potent, orally available inhibitor of Aurora kinases, exhibits signifficant anti-proliferative activity against a wide range of tumor cells both in vitro and in vivo (A549 EC50=9 nM).
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DC10357 Cenerimod
Cenerimod (ACT-334441) is a potent and orally available sphingosine 1-phosphate 1 receptor (S1P1) agonist extracted from patent WO 2016184939 A1 and WO 2011007324 A1, example 1, with an EC50 of 2.7 nM.
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DC23359 CeMMEC2
CeMMEC2 is a novel potent BRD4 inhibitor with IC50 of 0.9 uM, binds to both bromodomains of BRD4, comparably to (S)-JQ1..
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DC7569 Z-LEHD-FMK
Cell permeable fluoromethyl ketone (FMK)-derivatized peptides act as effective irreversible Caspase inhibitors with no cytotoxic effects and, therefore, are useful tools for studying Caspase activity.
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DC12245 Ceftizoxime
Ceftizoxime is a bacterial inhibitor which acts by interfering with bacterial cell wall synthesis and inhibiting cross-linking of the peptidoglycan.
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DC9355 Ceftibuten (dihydrate)
Ceftibuten dihydrate is a third-generation cephalosporin antibiotic.
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DC8687 Cefpirome sulfate
Cefpirome Sulfate is a fourth generation cephalosporin antibiotic.
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DC9356 Cefpiramide (sodium)
Cefpiramide sodium (SM-1652; Wy-44635) is a new Pseudomonas-active cephalosporin with a broad spectrum of antibacterial activity.
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DC20190 Cefoxitin
Cefoxitin is a beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity.
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DC9358 Cefmenoxime (hydrochloride)
Cefmenoxime hydrochloride is a third-generation cephalosporin antibiotic.
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DC8686 Cefetamet pivoxil hydrochloride
Cefetamet pivoxil hydrochloride is an oral third generation cephalosporin antibiotic.
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DC20881 CE-245677
CE-245677 is a potent, selective, orally active, dual Tie2/Trk kinase inhibitor with IC50 of 4.7 nM, 1 nM for Tie2 and TrkA/B, respectively.
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DC22446 CE-224535
CE-224535 (PF-04905428) is a potent and selective P2X7 receptor antagonist with IC50 of 1.4 nM (inhibition of the release of lL-1b from monocytes stimulated by ATP).
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DC20880 CDP-840 hydrochloride
CDP-840 (CDP840.
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DC20879 CDP-840
CDP-840 (CDP840.
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DC9478 CDK9-IN-1
CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection.
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DC20921 CDK5 inhibitor 20-223
CDK5 inhibitor 20-223 (CP 668863) potent, selective, ATP-competitive CDK2/5 inhibitor with IC50 of 6.0 and 8.8 nM for CDK2/CyclinE and CDK5/p35, with little to no activity against CDK1/4/6/7/9.
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DC11872 CDK12 inhibitor E9 S-isomer
CDK12 inhibitor E9 S-isomer (E9, CDK12-IN-E9) is a clinical analog of THZ1 and a selective, covalent CDK12 inhibitor that is not susceptible to ABC transporter-mediated drug efflux.
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DC11158 CDK12 inhibitor 2
CDK12 inhibitor 2 is a potent, selective, non-covalent CDK12 inhibitor with IC50 of 52 nM, displays >192-fold selectivity over CDK2/7/8/9.
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DC22051 CDD-450
CDD-450 is an unique inhibitor that selectively blocks p38α activation of proinflammatory kinase MAPK-MK2 while sparing p38α activation of PRAK and ATF2.
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DC10432 CDD3506
CDD3506 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.
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DC10433 CDD3505
CDD3505 is used for elevating high density lipoprotein cholesterol (HDL) by inducing hepatic cytochrome P450IIIA (CYP3A) activity.
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DC21877 Cdc7 inhibitor
Cdc7 inhibitor is a potent inhibitor of Cdc7 kinase with pIC50 of 10.01 against CDC7/DBF4 in TR-FRET assays..
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DC20877 S8
Cdc25 inhibitor S8 is an anti-fungal small molecule that inhibits cdc25 phosphatase with Ki of 140 uM.
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DC10955 CD12681
CD12681 (CD-12681) is a potent, selective RORγ inverse agonist with IC50 of 19 nM, displays no activity against a panel of nuclear receptors (RORα, RARγ, LXRβ, PPARγ and VDR).
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DC12549 CCX-354
CCX-354 (GSK-2941266, CCX354-C, CCX354) is a potent, selective, orally-available CCR1 antagonist for the treatment of inflammatory diseases such as rheumatoid arthritis (RA)..
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DC10206 CCX140
CCX140 is a potent CCR2 antagonist.
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DC9969 CCT251921
CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM).
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DC9399 CCT241533 (hydrochloride)
CCT241533 Hcl is a potent serine/threonine checkpoint kinase (Chk2) inhibitor with IC50 of 3 nM; shows minimal cross-reactivity against a panel of kinases at 1 uM.
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DC23828 CCT241161
CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively)..
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