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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC11781 T-3764518
T-3764518 (T 3764518, T3764518) is a novel potent, orally active SCD1 inhibitor with binding IC50 of 4.7 nM for hSCD1.
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DC21721 T-226296
T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
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DC26101 T-1840383
T-1840383 is a potent, ATP-competitive, dual c-Met/VEGFR-2 inhibitor with IC50 of 1.9, 7.7, 2.2 and 5.5 nM for c-Met, VEGFR1, 2 and 3, respectively.
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DC21720 T-155535
T-155535 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 21 uM in AlphaScreen assay.
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DC11226 T1551
T1551 is a novel selective PRMT5 inhibitor with IC50 of 34.1 uM, decreases cell viability of A549 cell with IC50 of 5.8 uM (72h).
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DC21719 T-1105
T-1105 is a broad-spectrum antiviral inhibitor that demonstrates good activity for various RNA viruses, including influenza virus, arenaviruses, bunyaviruses, West Nile virus (WNV), yellow fever virus (YFV), FMDV, and ZIKV.
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DC22242 T-025
T-025 (T025, CLK inhibitor T-025) is an orally available, potent inhibitor of Cdc2-like kinases (CLKs) with Kd of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, also inhibits DYRK1A and DYRK1B with IC50 of 0.074 and 1.5 nM.
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DC12418 SynuClean-D
SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence.
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DC20562 Syn-TEF1 intermediate 1
Syn-TEF1 intermediate 1 is a chemcal intermediate for Syn-TEF1 synthesis, which is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia..
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DC8308 SYM2206
SYM2206 is a novel, potent, non-competitive AMPA receptor antagonist (IC50 = 2.8 μM ).
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DC23846 Syk-IN-23
Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model..
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DC22240 SYC-435
SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
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DC21714 SW-083688
SW-083688 (SW083688) is a potent, highly selective TAOK2 (Thousand-And-One Kinase 2, MAP3K17) inhibitor with IC50 of 1.3 uM.
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DC10964 SW063058
SW063058 is a small molecule that selectively disrupt Beclin 1/Bcl-2 binding as compared to Bax/Bcl-2 and Bim/Bcl-2 binding and induces autophagic flux at concentrations with minimal cytotoxicity..
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DC23819 SW-034538
SW-034538 is a potent TAOK2 (Thousand-And-One Kinase 2.
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DC22239 SUVN-G3031 dihydrochloride
SUVN-G3031 (SUVN-G 3031) is a potent, selective, orally active histamine H3 receptor (H3R) inverse agonist with Ki of 8.73 nM (hH3R).
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DC21713 SUVN-502
SUVN-502 (SUVN502, Masupirdine) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.
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DC21712 SUVN-502 mesylate hydrate
SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.
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DC21711 SUVN-502 mesylate
SUVN-502 (SUVN502) is a potent, selective, brain penetrant and orally active 5-HT6 receptor antagonist with Ki of 2.04 nM.
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DC20559 Surfen
Surfen is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.
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DC20560 Surfen hydrate
Surfen hydrate is a small molecule antagonist of heparan sulfate, binds to heparin, low molecular weight heparins, and to HS and other GAGs.
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DC9550 Sunifiram
Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam.
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DC10246 Sulisobenzone
Sulisobenzone is an ingredient in some sunscreens which protects the skin from damage
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DC10268 (+/-)-Sulfinpyrazone
Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
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DC10264 Sulfabenzamide
Sulfabenzamide is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of an
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DC23769 Sudemycin K
Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.
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DC23770 Sudemycin E
Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing.
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DC10230 Sucralfate
Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus
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DC12232 Suberylglycine
Suberylglycine is an acyl glycine, which is a normally minor metabolite of fatty acid.
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DC20177 Suberohydroxamic acid;suberic bishydroxamic acid
Suberohydroxamic acid is a competitive HDAC inhibitor with IC50 values of 0.25 and 0.3 μM for HDAC1 and HDAC3 respectively.
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