ATUX-8385 is a potent PP2A activator. ATUX-8385 binds to PR65 subunit. ATUX-8385 has the potential for the research of cancers and chronic conditions such as Alzheimer’s disease and chronic obstructive pulmonary disease.

Atebimetinib is an inhibitor for MEK tyrosine kinase and exhibits antineoplastic activity.

ATC-324 is an bivalent AR (Androgen Receptor) degrader based on the protein degradation technology platform AUTOphagy-TArgeting Chimera (AUTOTAC). ATC-324 induces the formation of AR/p62 complex, leading to autophagy-lysosomal degradation of AR. ATC-324 can reduce nuclear AR levels and downregulate target gene expression of AR and AR-v7, and also has a degradation effect on common AR mutants in PCa.

ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of <1 nM. ASTX295 specifically blocks the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, and then inducing the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 is promising for research of lymphoid malignancies, such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.

Aspochracin is an insecticidal substance and a cyclotripeptide which can be extracted from Aspergillus ochraceus. Aspochracin can be utilized in insecticidal research.

AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay). AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 <1 μM. AS-254s induces the differentiation of MLL1-r leukemic cell.

Aplysin is a brominated sesquiterpene with an isoprene backbone that exhibits hepatoprotective, immunomodulatory, and antitumor activities. Aplysin effectively prevents spontaneous pancreatic necrosis and inflammatory responses in NOD mice.

APL-1091 (Mal-Exo-EEVC-MMAE) is part of a Drug-linker conjugate for ADC. APL-1091 contains a Mal-Exo-EEVC linker and MMAE (Microtubule inhibitor). APL-1091 can be used for ADC synthesis.

API32 is a potent Pin1 inhibitor. API32 interactes with the Pin1 PPIase domain. API32 inhibits cell proliferation and migration. API32 has the potential for the research of hepatocellular carcinoma (HCC).

APD-94 is a dual inhibitor targeting tubulin and Bmi-1. APD-94 interfers tubulin normal polymerization. APD-94 suppresses the expression of Bmi-1. APD-94 causes cell cycle arrest at the G2/M phase in cancer cells and induces apoptosis, thus inhibiting cancer cell proliferation. APD-94 represses the growth of HT29 cell xenografts in NOD/SCID mice. APD-94 can be used for colorectal cancer study.

Antibiotic adjuvant 3 (compound 8g) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 3 has minimum re-sensitizing concentration of 0.25 μg/mL agnist of Escherichia coli AR-0493.

Antibiotic adjuvant 2 (compound 5q) is an antibiotic adjuvant with potent colistin-potentiating activity and low mammalian toxicity. Antibiotic adjuvant 2 has minimum re-sensitizing concentration of 0.125 μg/mL agnist of Escherichia coli AR-0493.

AMPTX-1, a molecular glue, a potent and selective, reversibly covalent BRD9 degrader via recruitment of BRD9 to the E3 ligase DCAF16.

AMPRO-222 is a PROTAC linker that can act as a linker of PROTAC PROTAC BRD4 Degrader-29.

Aminoquinol is a GFRα-1 agonist. Aminoquinol exhibits neurotrophic effects similar to GDNF and induces Ret autophosphorylation in Neuro-2A cells. Aminoquinol can be used in research related to Parkinson's disease.

AMG28 is a Tau tubulin kinase 1 (TTBK1) and TTBK2 inhibitor with IC50s of 805 nM and 988 nM, respectively. AMG28 inhibits tau phosphorylation at Ser422 (IC50 of 1.85 μM).

AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17.

Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM.

Almoxatone is an orally effective, long-acting inhibitor of MAO-B.

AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC50 of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan.

AIM4 is a compound that can inhibit the aggregation of TDP-43. AIM4 has good biocompatibility and anti-inflammatory activity. AIM4 can be used in the research of diseases such as amyotrophic lateral sclerosis.

A181 (AI-181) is a DENV-2 inhibitor. A181 can be used for anti-dengue studies.

ADC-5 drug-linker is a drug-linker conjugate for ADC with potent anti-tumor activity. ADC-5 drug-linker can be used to synthesize NLRP3 agonist 3 in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect.

Aceclofenac ethyl ester is an impurity of Aceclofenac.

ABT-518 is a matrix metalloproteinase inhibitor with anti-tumor activity. ABT-518 has potent inhibitory effects on gelatinase A and gelatinase B, which can inhibit tumor growth and metastasis.

ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential.

AA-dUTP tetrasodium is an amine-modified nucleotide that has been used in the synthesis of fluorescently labeled dUTP.

A-39183A is an antibiotic that shows significant cytotoxicity to HeLa cells, with an IC50 value of 1.8 μM.

8-Sulfamoyloctanoic acid is a PROTAC linker that can be used in the synthesis of PROTAC XZ338.

8-prenylchrysin is a C8-prenylated flavonoid. 8-prenylchrysin inhibits P-gp. 8-prenylchrysin can be used for tumor research.