8-BuS-AMP is a CD39 and CD73 dual inhibitor. 8-BuS-AMP inhibits human CD39, mouse CD39 and human CD73 with Kis of 0.292, 2.19 and 1.19 μM, respectively.

7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA.

7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo.

7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect.

7-Azaspiro[3.5]nonane-piperidine-Boc is a PROTAC linker. 7-Azaspiro[3.5]nonane-piperidine-Boc can be used to synthesize RP03707 in neuroblastoma cells.

6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone.

6α-Hydroxy metandienone is an androgenic anabolic steroid metabolite of Metandienone.

6-Epi-doxycycline is the C-6 epimer of Doxycycline, formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations.

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively.

6-Alkyne-F-araNAD is an irreversible inhibitor of CD38. 6-Alkyne-F-araNAD helps other fluorescent probes (such as SR101−F-araNMN) to more clearly observe the localization of intracellular CD38.

6,2′,4′-Trimethoxyflavone is an AhR antagonist and has failed to show effective protective effects against cerebral ischemia/reperfusion injury in Sprague-Dawley rats.

6-(4-Azidobutanamido) hexanoic acid is a PROTAC Linker that can be used to synthesize the PROTAC molecule NR-11c.

5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 µM.

5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4.

5'-Hydroxy meloxicam is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Meloxicam.

5-Hexynal (compound 3) is a PROTAC linker that can be used to prepare the PROTAC product iRucaparib-TP3.

5-Fluoro-L-tryptophan is a competitive vesicular glutamate transporter (VGLUT) inhibitor. 5-Fluoro-L-tryptophan is promising for research of diseases associated with the neurotransmitter systems.

5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.

4-Phenyl-1,2,3-thiadiazole is an CYP2B4 and CYP2E1 inhibitor. 4-Phenyl-1,2,3-thiadiazole inhibits the oxidation of 1-phenylethanol to acetophenone by CYP2B4 and CYP2E1.

4-Hydroxyresveratrol (3,4,5,4'-Tetrahydroxystibene), a Resveratrol. HA14-1 is a Bcl-2/Bcl-xL antagonist with an IC50 of approximately 9 μM against Bcl-2.

4-Hydroxyisophthalic acid activates antioxidant enzymes (such as catalase CAT and superoxide dismutase SOD), scavenges free radicals, and exhibits antioxidant property. 4-Hydroxyisophthalic acid activates AChE and BChE, enhances neuronal function and improves Tau-induced neurobehavioral defects. 4-Hydroxyisophthalic acid improves the cognitive defects, and ameliorates circadian rhythm disorders of fruit flies.

4-Hydroxy-1-piperidinepropanamide is a PROTAC linker that can be used in the synthesis of PROTAC DDR1 degrader-1. Quinacainol dihydrochloride is an inhibitor for sodium current with an EC50 of 95 µM. Quinacainol dihydrochloride exhibits antiarrhythmic activity by affecting the electrophysiological properties of the heart.

4-Desmethyl-2-methyl celecoxib (Compound 1g) is an orally active and selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 value of 0.069 μM. 4-Desmethyl-2-methyl celecoxib shows anti-inflammatory, analgesic, and antipyretic activities. 4-Desmethyl-2-methyl celecoxib can reduces the synthesis of prostaglandins. 4-Desmethyl-2-methyl celecoxib is promising for research of inflammatory diseases and pain-related diseases, such as rheumatoid arthritis and osteoarthritis.

4ʹ-Chloro deschloroalprazolam is a benzodiazepine compound and is a derivative of alprazolam.

4,6,4'-Trihydroxy-3'-methoxyaurone is an herbicide. At concentrations of 100 and 1000 µg/mL, 4,6,4'-Trihydroxy-3'-methoxyaurone is able to inhibit the growth of rape root and barnyardgrass seedlings1.

4-(Azidomethyl)-L-phenylalanine is an unnatural amino acid with an azidomethyl group at position 4 of L-phenylalanine. 4-(Azidomethyl)-L-phenylalanine can be used as a reporter for probing protein hydration through addition of an azide group.

3-Penten-2-one (Ethylideneacetone) inhibits nitric oxide production and inducible nitric oxide synthase expression via heme oxygenase-1 induction in RAW264.7 macrophages activated with Lipopolysaccharides (LPS).

3-O-Demethylfortimicin A (A-49759) is an aminocyclitol antibiotic with antibacterial activity. 3-O-Demethylfortimicin A is particularly effective against Gram-negative pathogens and staphylococcus.

3'-Hydroxy stanozolol is a major metabolite of the anabolic androgenic steroid Stanozolol.

3'-Deoxy-GTP (3′-Deoxyguanosine 5′-triphosphate) trisodium, an analog of GTP, is a RNA chain terminator and suppresses RNA synthesis. 3'-Deoxy-GTP trisodium inhibits DENV NS5 RdRp (IC50: 0.02 μM).