Potent antiproliferative agent, binding to the “colchicine binding site” on tubulin and inhibiting tubulin polymerization in vitro

Novel inhibitor of sterol 14a-demethylases (CYP51)

Selective 5-HT2B/2C receptor antagonist

Novel immunostimulatory monosaccharidic lipid A analog, down-regulating TNF-alpha and IL-6 production and priming secretion of G-CSF and IL-1 beta

Novel inhibitor of the Golgi complex (Vrg4); Antifungal

Selective, surmountable antagonist for 5-HT4 receptors

Potent inhibitor of MMP-2, -3, -9, -8, -13, and -14

Novel irriversible selective PDI inhibitor, selectively labeling protein disulfide isomerase and inhibiting its enzymatic activity, showing unique cytotoxicity in cells derived from multiple myeloma

NRTI-drug pair of zidovudine (AZT)-didanosine (ddI), being highly cytotoxic and mutagenic

Novel inhibitor of nNOS-PSD-95 interaction, exhibiting neuroprotective activities in NMDA-induced or Oxygen and glucose deprivation (OGD)-induced neuronal damage in primary cortical neurons cultures, and ameliorating focal cerebral ischemic damage in rats

Novel dual acetylcholinesterase inhibitor (AChEI) and a calcium channel blocker (CCB)

Novel Inhibitor of p53-Murine Double Minute 2 (MDM2) Interaction and Histone Deacetylases (HDACs) with the IC50 values of 140, 910 and 17.5 nmol/L against MDM2, HDAC1, and HDAC6, respectively, showing the tumor growth inhibition (TGI) in the A549 xenograf

Selective, ATP-competitive p38

Novel inhibitor of SARS-CoV-2 main protease (MPro)

Novel inhibitor of SARS-CoV-2 main protease (MPro)

Novel glucose transport inhibitor

Novel Lysine-Specific Demethylase 1 (LSD1) Inhibitor (IC50: 20nM)

Novel inhibitor of vanilloid receptor subtype 1 (VR1)

Novel inhibitor of SARS-CoV-2 main protease (MPro)

Novel potent and selective glucagon receptor antagonist

Novel histamine H3-receptor antagonist

Inhibitor of p21-hRas nucleotide exchange in vitro

Novel Acyl_carrier_protein_synthase>acyl carrier protein synthase inhibitor; Inhibitor of growth of the bacteria Streptococcus_pneumoniae>Streptococcus pneumoniae and Neisseria_gonorrhoeae>Neisseria gonorrhoeae

Potent and selective PDE1 and PDE5 inhibitor

Non-​nucleoside antiviral agent, having potent and selective activity against herpes simplex virus type 2 (HSV-​2)

Novel, orally active phosphodiesterase 4 (PDE4) inhibitor

D1 dopamine receptor antagonist

Precursor for radioiosotopically labelled R(+)-SCH-23390

Novel Inhibitor of the virus fusion to its cell receptor, targeting SARS-CoV-2 spike protein HR1

Novel Inhibitor of the virus fusion to its cell receptor, targeting SARS-CoV-2 spike protein HR1