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SHIN2

  Cat. No.:  DC60152   Featured
Chemical Structure
2204289-53-0
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Field of application
SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2204289-53-0
Chemical Name: SHIN 2, SHIN-2
Synonyms: 6-Amino-4-(3-(hydroxymethyl)-5-(5-hydroxypent-1-yn-1-yl)phenyl)-4-isopropyl-3-methyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile
SMILES: N#CC(C1(C2=CC(C#CCCCO)=CC(CO)=C2)C(C)C)=C(N)OC3=C1C(C)=NN3
Formula: C23H26N4O3
M.Wt: 406.49
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
Publication: 1) Juan C. García-Cañaveras et. eal., SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia, Leukemia volume 35, pages377–388 (2021)
Description: SHIN-2 is a novel SHMT inhibitor, increasing survival in NOTCH1-driven mouse primary T-ALL in vivo
References: 1) Juan C. García-Cañaveras et. eal., SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia, Leukemia volume 35, pages377–388 (2021)
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