Novel macrocycle antibiotic with selective and potent activity against P. aeruginosa

Novel RNA polymerase I inhibitor, targeting ribosomal DNA G-quadruplexes, potently and selectively inhibiting cell growth by high-affinity binding to G4s in ribosomal DNA, impairing RNA polymerase I (Pol I) elongation, inducing a rapid inhibition of Pol I

Novel microtubule destabilizing natural product from the Podophyllum species

The first small-molecule approach capable of detecting and controlling engineered cell-cell outputs

Allosteric modulator of 5-HT(2C)R with no intrinsic agonist activity

Potent inhibitor of CDK2/cyclin A

Novel G Protein-Biased Cannabinoid 1 (CB1) Receptor Agonist

Cell-permeable analog of pifithrin-α, potently blocking p53-mediated expression of p21/WAF1 and apoptosis

Selective 5-HT1A serotonin receptor antagonist

Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway

Novel inhibitor of prenylated methylated protein methyl esterase (PMPMEase), a key enzyme in the reversible methylation/demethylation step in the protein prenylation pathway

Novel potent irriversible dual inhibitor of tubulin and epidermal growth factor receptor (EGFR), inducing the apoptosis of A549 cells in a dose- and time-dependent manner, along with decrease in mitochondrial membrane potential (MMP), production of ROS an

Novel inhibitor of β-catenin signaling, significantly reduced β-catenin activity in hepatoblastoma and several HCC cells

Potent anticancer tetrahydroisoquinoline alkaloid, being able to form a covalent bond with the amino group of a guanine in selected triplets of DNA duplexes and eventually give rise to double-strand breaks

Slightly less potent inhibitor of FMS than PLX647 but has better aqueous solubility

Novel polo-like kinase 1 (PLK1) inhibitor

Novel Inhibitor of the Polo-Box Domain of Polo-like Kinase 1 (Plk1 PBD)

Plk1 PBD-specific phosphopeptide inhibitor, effectively inhibiting mitotic progression and cell proliferation

Novel activator of AMPK, inducing apoptotic death in prostate cancer cells

Novel enhancer of Reactive Oxygen Species (ROS), depleting glutathione levels in analogy to piperlongumine but with reduced cell death

Novel inhibitor of phospholipase C (PLC) isozyme

Broad spectrum aminoglycoside antibiotic typically used for moderate-to-severe urinary tract infections or pyelonephritis

Gastroprotective agent, increasing the prostaglandin production in the gastric mucosa and accelerates ulcer healing

Novel Potent Activator of the Nonreceptor Protein Tyrosine Phosphatase Shp2

Novel Potent and Specific Inhibitor of Placental Alkaline Phosphatase (PLAP; IC 50 = 32 nM), Targeting Tumor of the Female Reproductive Tract

Antilipidemic and antiplatelet agent

Potent inhibitor of HipA toxin, inhibiting E. coli persistence

Novel potent and specific β5i inhibitor

Novel highly potent and selective PKM2 inhibitor, blocking PKM2 mitochondrial translocation under nutritional stress and inhibits tumor growth in vivo

Novel selective inhibitor of protein kinase Cθ (PKCθ)