Novel selective activator for TREK, against other two-pore domain K (K2P) channels

Novel multi-functional resveratrol derivative for the treatment of atrial fibrillation

FPP analogue, bearing an alkyne group to allow for post-prenylation protein labeling

Novel broad-spectrum intracellular targeting antibacterial agent, interacting with the 70S ribosome of E. coli and inhibiting its protein synthesis, demonstrating superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S.

Novel broad-spectrum intracellular targeting antibacterial agent, interacting with the 70S ribosome of E. coli and inhibiting its protein synthesis, demonstrating superior clearance of bacteria from the spleen, liver, and kidneys of mice, infected with S.

Novel sensitizer of BRAF wild-type melanoma cells to vemurafenib, significantly reducing melanoma cell viability, with limited toxicity for normal human fibroblasts

Natural inhibitor of BACE1

β-Hairpin Octapeptide, acting as a potent mouse melanocortin-4 receptor (mMC4R) antagonist

Novel potent and selective PTP-1B inhibitor

Novel promising spectroscopic probe for inositol 5-phosphatase(s)

Novel Gemini vitamin D analog, targeting CD44-STAT3 signaling and inhibiting breast cancer invasion

Highly selective inhibitor of AChE

Novel BB2 receptor antagonist. attenuating the feeding responses evoked by exogenous gastrin releasing peptide-29

Selective 11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) inhibitor

Novel 11β-HSD1 inhibitor

Natural inhibitor of microRNA-21, reducing growth of cancer cells

Potent inducer of anemia

Direct-acting vasodilator with anti-tachycardiac effect

Potent and selective agonist of μ-opioid receptor (MOR) with relatively low affinity for the δ-opioid receptor and the κ-opioid receptor

Negative control for BTZO-1

Novel effective reversible and noncovalent inhibitor of DprE1.

Novel unique Na V modulator, acting as a conspicuous outlier, eliminating fast but not slow inactivation

Novel inhibitor of alpha2beta1 integrin, decreasing average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C

The first small-molecule inhibitor with significant selectivity among the KCa2 channel subtypes

Novel potent inhibitor of Bruton’s tyrosine kinase (BTK)

Novel potent and selective covalent inhibitor of Bruton’s tyrosine kinase (BTK), targeting a noncatalytic cysteine residue (Cys481) for covalent bond formation

Novel selective and potent competitive inverse agonist of human GPR43

Novel activator of BtGH84, the first experimentally discovered small molecule activator of a glycoside hydrolase

Novel activator of PC1/3 and inhibitor of PC2

Novel cell-permeable modulator of cellular morphogenesis in yeast and mammalian cells