Novel anti-HIV active dimeric prodrug of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate (d4TMP)

Novel adjuvant to repurpose azithromycin for use against Pseudomonas aeruginosa, exhibiting a 1024-fold reduction in the minimum inhibitory concentration of azithromycin in vitro and displays activity in a Galleria mellonella model of infection

Potent peptide opioid receptor agonist, alleviating LPS-Induced activation in rat primary microglial cultures in opioid receptor-dependent and receptor-independent manners

Potent inhibitor of SHIP-2 catalytic activity; Novel inositol polyphosphate surrogate modulating Ca responses in rat hepatocytes

Novel heparanase inhibitor

Novel selective RORgamma inhibitor, selectively inhibiting Th17 differentiation and RORgamma signature gene expression

Novel USP28 inhibitor

Potent HNF4α antagonist

Natural Biliary Toxin, causing extrahepatic biliary atresia

Novel potent blocker of Nav1.2 sodium channels, protecting of brain tissue from ischemia

Novel potent blocker of the NMDA receptor ion channel

Novel, Selective, Potent, Reversible Bruton's Tyrosine Kinase (BTK) Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases

Selective Syk inhibitor

Novel selective heat shock protein 90 inhibitor, prodrug of CF2772

Partial agonist at dopamine D2 and serotonin 1A receptors

Novel inhibitor of the TGF-β pathway, blocking the epithelial to mesenchymal transition

GABAA receptor antagonist

Antilipidemic agent

Triple reuptake inhibitor (TRI)

Potent, selective inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase

Novel, highly selective and potent irreversible BTK inhibitor

Novel nonpeptide angiotensin II receptor antagonist

Novel potent, highly selective, and orally bioavailable CATHEPSIN C (CTSC, CatC) inhibitor

Non-ATP competitive inhibitor of JNK, targeting the JNK-JIP interaction

Novel RORγ antagonist for the treatment of autoimmune diseases

Novel highly potent dual inhibitor of BRD9/BRD7

Novel potent and selective ATP-competitive inhibitor of glycogen synthase kinase (GSK-3), targeting both isoforms GSK-3α and GSK-3β

Novel potent and selective inhibitor of Alk5 (TGFßR1), blocking the phosphorylation of Smad2 and Smad3 in HaCaT cells

Novel inhibitor of HIV replication, preventing the formation of the capsid core structure that encapsulates the viral genome and its associated enzymes, reversing transcriptase and integrase

Novel highly selective, soluble and cellular permeable inhibitor of the P. falciparum protease dipeptidyl aminopeptidase 1 (DPAP1)