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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC76513 Clozapine dihydrochloride
Clozapine (HF 1854) dihydrochloride is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).
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DC76512 Aripiprazole N1-oxide
Aripiprazole N-oxide is a metabolite of the atypical antipsychotic Aripiprazole. Lenvatinib (E708
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DC76511 7-Hydroxy ropinirole bromide
7-Hydroxy ropinirole (SK&F 89124) bromide is a potent and highly selective DA2 receptor agonist, and a derivative of N,N-di-n-propyldopamine (DPDA). In isolated perfused rabbit ear artery models, 7-Hydroxy ropinirole (bromide) exerts its DA2 agonist effects by inhibiting neurotransmitter release or sympathetic nerve-induced responses. It shows potential for research in the fields of cardiovascular and neurological diseases.
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DC76510 2-Bromo-LSD
2-Bromo-LSD (BOL-148; Bromolysergide) is a Dopamine Receptor antagonist that directly affects dopamine neurons in the substantia nigra neostriatum. 2-Bromo-LSD increases the hydroxylation of tyrosine in striatum and antagonizes the decrease of Apomorphine-induced DOPA accumulation. 2-Bromo-LSD also blocks the 5-HT Receptor mediated DOPA formation.
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DC76509 Sut-8701
Sut-8701 is a Cholecystokinin analog that effectively slows the degenerative process of Alzheimer's disease by protecting the integrity of cholinergic neurons in the nucleus basalis.
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DC76508 CI-1015
CI-1015 is a potent CCK-B receptor antagonist.
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DC76507 A-70874
A-70874 is a tyrosine-free tetrapeptide analog of cholecystokinin (30-33) (CCK-4). A-70874 is an agonist that stimulates pancreatic amylase release and a partial agonist that stimulates pancreatic phosphoinositide decomposition. A-70874 has an IC50 of 4.9 nM for the guinea pig pancreatic CCK receptor. Cholecystokinin (CCK) receptors are divided into CCK-A (digestive tract) and CCK-B (brain). A-70874 has an affinity of 1.6 μM for the CCK-B/gastrin receptor.
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DC76506 Rimegepant sulfate hydrate
Rimegepant (sulfate hydrate) is an orally active, selective and competitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM. Rimegepant (sulfate hydrate) can be used in migraine related research.
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DC76505 Δ9-THCP acetate
Δ9-THCP acetate (Δ9-Tetrahydrocannabiphorol acetate) is structurally similar to known phytocannabinoids.
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DC76503 Δ9-THCBA-A
Δ9-THCBA-A (Δ9-Tetrahydrocannabinolic acid-C4) is structurally similar to known phytocannabinoids.
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DC76502 Δ9-Tetrahydrocannabiorcol
Δ9-Tetrahydrocannabiorcol is structurally similar to known phytocannabinoids.
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DC76501 Δ8-THCPA-A
Δ8-THCPA-A (Δ8-Tetrahydrocannabiphorolic acid) is structurally similar to known phytocannabinoids.
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DC76500 Δ8-THCP
Δ8-THCP (Δ8-Tetrahydrocannabiphorol; n-Heptyl Δ8-THC) (Compound 1a) is a semisynthetic cannabinoid that serves as an analytical reference standard and exhibits affinity for the CB1 receptor.
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DC76499 Δ8-THC-ethyl
Δ8-THC-ethyl (Ethyl-Δ8-Tetrahydrocannabinol) is structurally similar to known phytocannabinoids.
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DC76498 Δ8-THCBA-A
Δ8-THCBA-A (Δ8-Tetrahydrocannabibutolic acid A) is structurally similar to known phytocannabinoids.
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DC76497 Δ8-THCB
Δ8-THCB (∆8-Tetrahydrocannabutol) is a structural analog of phytocannabinoids. Δ8-THCB is also an analog of Δ8-tetrahydrocannabinol.
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DC76496 Δ8-THC methyl ether
Δ8-THC methyl ether (compound 3) shows a good docking score (-10.167 kcal/mol) for CB2 receptor. Δ8-THC methyl ether has antinociceptive activity in mice.
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DC76495 Δ8-THC Glucuronide
Δ8-THC Glucuronide is a phytocannabinoid metabolite.
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DC76494 Δ8-Tetrahydrocannabivarin
Δ8-Tetrahydrocannabivarin is a cannabinoid.
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DC76493 Δ8-iso-THC
Δ8-iso-THC is structurally similar to known phytocannabinoids.
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DC76492 Δ4-Iso-THC
Δ4-Iso-THC (Δ4-Iso-tetrahydrocannabinol) is a cannabidiol derivative with potential cytotoxicity targeting cancer cells.
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DC76491 Δ4(8)-iso-THC
Δ4(8)-iso-THC (Δ4(8)-Isotetrahydrocannabinol) is structurally similar to known phytocannabinoids.
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DC76490 Surinabant
Surinabant (SR 147778) is an orally active, selective cannabinoid receptor type 1 CB1R antagonist. Surinabant is used in studies of obesity and alcoholism.
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DC76489 Rezosicone
Rezosicone is the antagonist for cannabinoid CB1 receptor.
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DC76488 PTI-1
PTI-1 is a synthetic cannabinoid (CB) that contains the 1-pentyl-indole structure.
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DC76487 ortho-CBNQ
ortho-CBNQ (o-Cannabinolquinone) is an oxidative byproduct of Cannabidiol.
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DC76486 O-2545 hydrochloride
O-2545 hydrochloride is a highly potent, water-soluble CB1/CB2 receptor agonist (with Ki values of 1.5 and 0.32 nM for CB1 and CB2 respectively), can be used for epilepsy, pain, multiple sclerosis research.
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DC76485 NAPIE
NAPIE is structurally similar to known synthetic cannabinoids.
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DC76484 MEP-FUBICA
MEP-FUBICA is structurally categorized as a synthetic cannabinoid.
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DC76483 MDMB-FUBICA metabolite 3
MDMB-FUBICA metabolite 3 is structurally classified as a synthetic cannabinoid. MDMB-FUBICA metabolite 3 is a metabolite of MDMB-FUBICA.
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