Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity

DT-diaphorase inhibitor

Selective potentiator at GluN1/GluN2C and GluN1/GluN2D receptors

Novel potent Mycobacterium tuberculosis DHFR inhibitor

Potent inhibitor of the AcrAB-TolC efflux pump in Escherichia coli, potentiating the antibacterial activities of novobiocin and erythromycin upon binding to the membrane fusion protein AcrA

Novel selective inhibitor of TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification, effectively inhibiting cell viability in AML with high expression of TET1

Novel inhibitor of Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations

Novel potent gonist of Human G Protein-Coupled Receptor-35 (hGPR35) (EC50 8 nM)

Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity

Novel Inhibitor of the p53-mdm2 Interaction, Activating p53-Dependent Transcription in mdm2-Overexpressing Cells

Novel substrate of ABCG2

Specific Ligand for Stem Loop 3 Ribonucleic Acid of the Packaging Signal Ψ of Human Immunodeficiency Virus-1

Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity

Novel 3C-like protease inhibitor of SARS-CoV-2

Novel potent SHP2 Inhibitor with Anti-Proliferative Activity in Breast Cancer Cell Lines

Novel inhibitor of ABCG2 transporter function

Capturer of kinase-insertion domain receptor (KDR) from a solution, while allowing the captured KDR to bind with the solution-phase vascular endothelial growth factor (VEGF)

Novel inhibitor of growth of intracellular Mycobacterium tuberculosis, inducing autophagy in differentiated THP-1 macrophages

Non-nucleoside reverse transcriptase inhibitor

Selective G-quadruplex inducer of the human telomeric sequence; Stabilizer of the G-quadruplex formed by the MYC promoter sequence; Anti-neoplastic effects in wild-type p53, p53-mutant or p53-deficient human colon cancer cells.

Novel potent and selective serotonin reuptake inhibitor (SSRI)

Specific inhibitor of ERCC1-XPF with no effect on both HhaI and XPG

Inhibitor of the RUNX1-CBFβ interaction

Novel inhibitor of Nef-calnexin interaction

HIF-pathway inhibitor

Novel potent SHP2 Inhibitor with Anti-Proliferative Activity in Breast Cancer Cell Lines

Novel inhibitor of the second bromodomain (BD2) of the BET family protein BRD2

Apoptosis inducer; Antitumor agent

Selective non-lipid agonist of LPA2/3

Selective inhibitor of shp2 protein tyrosine phosphatase (PTP)