Phylloflavan is an antileishmanial agent with an intracellular EC50 of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL).

NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research.

USP10 inhibitor Wu-5 (Wu-5) is a novel small molecule USP10 inhibitor inducing the degradation of FLT3-mutated protein, directly interacts and inactivates USP10, the deubiquitinase for FLT3-ITD in vitro (IC50=8.3 uM) and in FLT3-ITD-positive AML cells.Wu-5 selectively inhibited the viability of FLT3 inhibitor-sensitive (MV4-11, Molm13) and -resistant (MV4-11R) FLT3-ITD-positive AML cells with IC50 of 3.794, 5.056, and 8.386 uM, respectively.Wu-5 (1-10 μM) dose-dependently induced apoptosis of MV4-11, Molm13, and MV4-11R cells through the proteasome-mediated degradation of FLT3-ITD.Combined treatment of Wu-5 and crenolanib produced synergistic cell death in FLT3-ITD-positive cells via the reduction of both FLT3 and AMPKα proteins.

Novel SIRT6 activator, significantly inhibiting the proliferation and migration of pancreatic ductal adenocarcinoma (PDAC) cells in vitro and markedly suppressing the tumor growth in a PDAC tumor xenograft model

Novel fluorescent substrate for both the serotonin transporter and the vesicular monoamine transporter 2 (VMAT2)

A stable, orally active, non-prostanoid prostacyclin I2 (PGI2) mimetic and prostacyclin agonist with inhibitory activity against thromboxane A2 synthase.

MAP4343 is the 3-methylether derivative of Pregnenolone. MAP4343 binds in vitro to microtubule-associated protein 2 (MAP2), stimulates the polymerization of tubulin, enhances the extension of neurites and protects neurons against neurotoxic agents.

RU-521 (RU.521, RU-320521) is a potent, selective cyclic GMP-AMP synthase (cGAS) inhibitor with Kd of 36.2 nM.

A fourth-generation synthetic fluoroquinolone, broad-spectrum antibacterial agent that is active against both Gram-positive and Gram-negative bacteria.

FT-671 is a novel potent, specific, non-covalent USP7 inhibitor with Kd of 65 nM (USP7 catalytic domain).

ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.

(E)-Flupentixol is a non-neuroleptic isomer of (Z)-flupenthixol.

PF-06279794, also known as PF-794, is a potent, selective and ATP-competitive TNIK inhibitor.

GSK-3 Inhibitor XIII is a potent and ATP-competitive GSK-3 inhibitor with a Ki of 24 nM.

PF-CBP1, also known as PF-06670910, is potent and highly-selective inhibitor of the bromodomain of CREB binding protein (CBP BRD) that down regulates targets of CBP in macrophages primary neurons.

JTE 013 is a potent and selective S1P2 antagonist with IC50 of 17.6 nM.

HA-155 is a potent and selective autotaxin (ATX) inhibitor with an IC50 of 5.7 nM.

Dapansutrile is a β-sulfonyl nitrile inhibitor of the NLRP3 inflammasome that inhibits the release of IL-1β and decreases caspase-1 levels in LPS-stimulated J774A.1 murine macrophages, human monocyte derived macrophages (HMDMs), and primary human blood ne

ML-261 is a thienopyrrole-5-carboxamide that inhibits lipid droplet formation.

cis-ISRIB is a weak inhibitor of PERK signaling compared to trans-ISRIB , potently reverses the effects of eIF2α phosphorylation with IC50 of 600 nM.ISRIB reduces the viability of cells subjected to PERK-activation by chronic endoplasmic reticulum stress, displays significant enhancement in spatial and fear-associated learning.ISRIB is a potent inhibitor of the integrated stress response (ISR)integrated stress response (ISR).

Lung endothelium-targeted Lipid-1 is used in pulmonary endothelium targeted mRNA delivery. Lung endothelium-targeted Lipid-1 formulated nanoparticle, Lung-LNP (LuLNP) is capable of delivering therapeutic mRNA cargo for vascular repair in influenza infection.

Compound 11 (EBP inhibitor) is a selective orally bioavailable, brain-penetrant emopamil binding protein (EBP) inhibitor with EC50 of 44 nM. Compound 11 enhances the formation of oligodendrocytes in human cortical organoids.

SF 2312 is a highly potent, low-nanomolar inhibitor of Enolase with IC50 of 37.9 nM and 42.5 nM for recombinant hENO1 and hENO2 respectively.