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FLLL32

  Cat. No.:  DC7751   Featured
Chemical Structure
1226895-15-3
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More than 5000 active chemicals with high quality for research!
Field of application
FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1226895-15-3
Chemical Name: FLLL32,FLLL-32,FLLL 32
Synonyms: FLLL32,FLLL-32,FLLL 32
SMILES: O=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3
Formula: C28H32O6
M.Wt: 464.55
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: FLLL32 is a STAT3 inhibitor derived from the natural product curcumin. FLLL32 retains the cellular response to cytokines with anti-tumor activity[1].
In Vitro: FLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC46604 CMD178 CMD178 is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling. CMD178 also is an inhibitor of STAT5 and inhibit Treg cell development.
DC10139 Stat5 Inhibitor(STAT5-IN-1) Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain.
DC10105 SH5-07 SH5-07 is a hydroxamic acid based Stat3 inhibitor with an IC50 of 3.9±0.6 μM in in vitro assay.
DC7983 SH-4-54 SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5, respectively.
DC9691 Piperlongumine Piperlongumine induces cell death and increases the level of reactive oxygen species (ROS) in cancer cells with both wild-type and normal p53.
DC8474 Napabucasin (BBI608) Napabucasin (BBI608) is an orally-administered small molecule which can block cancer stem cell (CSC) self-renewal and induces cell death in CSCs as well as non-stem cancer cells.
DC10555 inS3-54A18 inS3-54A18 is a potent STAT3 inhibitor, with anti-cancer properties.
DC7751 FLLL32 FLLL32, a novel curcumin analogue, is a potent STAT3 inhibitor.
DC10864 C188-9 C188-9 is a potent inhibitor of STAT3 that binds to STAT3 with high affinity (KD=4.7±0.4 nM). C188-9 is well tolerated in mice, shows good oral bioavailability, and is concentrated in tumors.
DC11420 AS-1517499 AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
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