Tubulin inhibitor 6|CAS 105925-39-1|DC Chemicals

Cas No.:	105925-39-1
Chemical Name:	10H-Phenothiazine, 2-chloro-10-(4-methoxybenzoyl)-
SMILES:	COC1=CC=C(C=C1)C(=O)N2C3=C(C=CC(Cl)=C3)SC4C2=CC=CC=4
Formula:	C₂₀H₁₄NO₂Scl
M.Wt:	367.84866
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

Description:	Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1].
Target:	IC50: 0.87 μM (tubulin polymerization)[1]
In Vitro:	Tubulin inhibitor 6 displays submicromolar antiproliferative activity[1].
References:	[1]. Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63.

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