DCLK1-IN-1|CAS 2222635-15-4|DC Chemicals

Cas No.:	2222635-15-4
Chemical Name:	Dclk1-IN-1
SMILES:	FC(C([H])([H])N1C(C2=C([H])C([H])=C([H])C([H])=C2N(C([H])([H])[H])C2C1=C([H])N=C(N=2)N([H])C1C([H])=C([H])C(=C([H])C=1OC([H])([H])[H])N1C([H])([H])C([H])([H])N(C([H])([H])[H])C([H])([H])C1([H])[H])=O)(F)F
Formula:	C₂₆N₇O₂F₃H₂₈
M.Wt:	527.5414
Purity:	>98%
Sotrage:	-20

In Vivo:	DCLK1-IN-1 has a favorable pharmacokinetic profile in mice, with a half-life of 2.09 hours, an area under the curve of 5,506 h/ng ml and 81% oral bioavailability[1].
In Vitro:	DCLK1-IN-1 shows no significant activity against ERK5, ACK, and LRRK2. DCLK1-IN-1 potently binds DCLK1 in HCT116 cells (IC50 = 279 nM). DCLK1-IN-1 significantly inhibited DCLK1, and weakly inhibited ERK5, in PATU-8988T cell lysates and live cells[1].
References:	[1]. Ferguson FM, et al. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 Apr 6.

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Dclk1-IN-1