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B022

  Cat. No.:  DC28410   Featured
Chemical Structure
1202764-53-1
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More than 5000 active chemicals with high quality for research!
Field of application
​​B022​​ represents a breakthrough in targeted kinase modulation as a highly potent and selective NF-κB-inducing kinase (NIK) antagonist.
Cas No.: 1202764-53-1
Chemical Name: B022
Synonyms: B022;NCGC00346747;4-(1-(2-amino-5-chloropyrimidin-4-yl)indolin-6-yl)-2-(thiazol-2-yl)but-3-yn-2-ol;4-[1-(2-Amino-5-chloropyrimidin-4-yl)-2,3-dihydroindol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol;NCGC00346747-01;SCHEMBL1614292;AKOS040741285;MS-26722;BDBM50541592;B-022;4-[1-(2-Amino-5-chloro-pyrimidin-4-yl)-2,3-dihydro-1H- indol-6-yl]-2-thiazol-2-yl-but-3-yn-2-ol;4-[1-(2-amino-5-chloropyrimidin-4-yl)-2,3-dihydro-1H-indol-6-yl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol;4-[1-(2-Amino-5-chloro-pyrimidin-4-yl)-2,3-dihydro-1H-;CHEMBL3187788;NCGC00346747-02;1202764-53-1;indol-6-yl]-2-thiazol-2-yl-but-3-yn-2-ol;CS-0078192;HY-120501;EX-A9387;AT21709
SMILES: ClC1=CN=C(N)N=C1N1C2C=C(C#CC(C3=NC=CS3)(C)O)C=CC=2CC1
Formula: C19H16ClN5Os
M.Wt: 397.881240844727
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC71825 Chitosan oligosaccharide Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
DC44584 TCEP Hydrochloride TCEP (Tris(2-carboxyethyl)phosphine) hydrochloride, a non-thiol reducing agent, promotes NF-κB-DNA binding in a dose-related manner.
DC28670 DCZ0415 DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients.
DC28480 Urolithin B Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B inhibits NF-κB activity by reducing the phosphorylation and degradation of IκBα, and suppresses the phosphorylation of JNK, ERK, and Akt, and enhances the phosphorylation of AMPK. Urolithin B is also a regulator of skeletal muscle mass.
DC28410 B022 ​​B022​​ represents a breakthrough in targeted kinase modulation as a highly potent and selective NF-κB-inducing kinase (NIK) antagonist.
DC8872 Iguratimod Iguratimod is one of a series of 4H-1-benzopyran-4-ones which has potent anti-inflammatory, analgesic and antipyretic activity.
DC11926 NDMC101 A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
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