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NDMC101

  Cat. No.:  DC11926   Featured
Chemical Structure
1308631-40-4
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More than 5000 active chemicals with high quality for research!
Field of application
A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1308631-40-4
Chemical Name: N-(4-chloro-2-fluorophenyl)-2-hydroxybenzamide
Synonyms: NDMC-101;NDMC 101
SMILES: C(NC1=CC=C(Cl)C=C1F)(=O)C1=CC=CC=C1O
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A small molecule that inhibits NFATc1 and NF-κB activity, inhibits RANKL-induced osteoclastogenesis in vivo; markedly inhibits RANKL-induced formation of TRAP+ multinucleated cells in RAW264.7 and bone marrow macrophage cells (BMMs); significantly reduces the bone-resorbing activity of mature osteoclasts; reduces arthritic index and mitigated bone erosion in CIA mice.
In Vitro: NDMC101 (10-15 µM) inhibits RANKL-induced osteoclast differentiation of bone marrow-derived macrophages (BMDMs) and RAW 264.7 cells[1]. NDMC101 (15 µM) decreases RANKL-induced expression of the osteoclastogenic genes Nfatc1, Acp5, Ctsk, Oscar, Itgb3, and Dcstamp in BMDMs[1].
References: [1]. Chia-Pi Cheng, et al. A benzamide-linked small molecule NDMC101 inhibits NFATc1 and NF-κB activity: a potential osteoclastogenesis inhibitor for experimental arthritis. J Clin Immunol. 2012 Aug;32(4):762-77. [2]. Jun-Ting Liou, et al. A salicylate-based small molecule HS-Cm exhibits immunomodulatory effects and inhibits dipeptidyl peptidase-IV activity in human T cells. Eur J Pharmacol. 2014 Mar 5;726:124-32.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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