LY-3475070|cas 2375815-63-5|DC Chemicals

Cas No.:	2375815-63-5
Chemical Name:	5-(5-((1S,2R)-2-isopropylcyclopropyl)-6-methylpyridazin-3-yl)pyrimidine-2,4(1H,3H)-dione
Synonyms:	LY-3475070; LY 3475070; LY3475070;
SMILES:	O=C1NC(C(C2=NN=C(C)C([C@@H]3[C@@H](C(C)C)C3)=C2)=CN1)=O
Formula:	C₁₅H₁₈N₄O₂
M.Wt:	286.335
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO Application

Description:	LY-3475070 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1].
In Vitro:	LY-3475070 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively[1]. In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM[1].
References:	[1]. Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.

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