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CDDO-dhTFEA

  Cat. No.:  DC60189   Featured
Chemical Structure
1191265-33-4
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More than 5000 active chemicals with high quality for research!
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Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1191265-33-4
Chemical Name: CDDO-dhTFEA
Synonyms: CDDO-dhTFEA
SMILES: C1(C#N)=C[C@]2(C)[C@@]3([H])CC(=O)[C@]4([H])[C@]5([H])CC(C)(C)CC[C@]5(C(=O)NCC(F)(F)F)CC[C@@]4(C)[C@]3(C)CC[C@@]2([H])C(C)(C)C1=O
Formula: C33H45F3N2O3
M.Wt: 574.717220067978
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB[1]. CDDO-dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats[2].
Target: NF-κB Nrf2
References: [1]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease. Redox Biol. 2013 Oct 31;1:527-31. [2]. Aminzadeh MA, et al. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease. Xenobiotica. 2014 Jun;44(6):570-8.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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