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NCI-006

  Cat. No.:  DC60244   Featured
Chemical Structure
1964516-64-0
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More than 5000 active chemicals with high quality for research!
Field of application
NCI-006 is a potent new inhibitor of lactate dehydrogenase (LDH) that disrupts tumor growth in mice. LDH inhibition slows tumor growth but rapidly redirects pyruvate to support mitochondrial metabolism. Inhibiting both mitochondrial complex 1 and LDH suppresses metabolic plasticity of glycolytic tumors in vivo, significantly prolonging tumor growth inhibition.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1964516-64-0
Chemical Name: NCI-006
Synonyms: 2-[4-[[4-(Aminosulfonyl)-3-fluorophenyl]methyl]-5-(cyclopropylmethyl)-3-[4-fluoro-3-[2-(5-methyl-2-thienyl)ethynyl]phenyl]-1H-pyrazol-1-yl]-4-thiazolecarboxylic acid
SMILES: O=C(C1=CSC(N2N=C(C3=CC=C(F)C(C#CC4=CC=C(C)S4)=C3)C(CC5=CC=C(S(=O)(N)=O)C(F)=C5)=C2CC6CC6)=N1)O
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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