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Nedisertib (Synonyms: Peposertib; M3814)

  Cat. No.:  DC70085   Featured
Chemical Structure
1637542-33-6
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More than 5000 active chemicals with high quality for research!
Field of application
Nedisertib (M3814, MSC2490484A) is a highly potent, selective, orally bioavailable inhibitor of DNA-PK.
Cas No.: 1637542-33-6
Chemical Name: M-3814
Synonyms: nedisertib;peposertib;M3814;MSC2490484A;GN429E725A;(S)-(2-chloro-4-fluoro-5-(7-morpholinoquinazolin-4-yl)phenyl)(6-methoxypyridazin-3-yl)methanol;(S)-[2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol;Nedisertib [INN];nedisertib (deleted INN);GTPL9766;BDBM315715;MSC 2490484A;NSC802822;NSC816960;US10172859, Example 136;MSC 2490484A [W;HY-101570;PEPOSERTIB [WHO-DD];example 136 [WO2014183850];PEPOSERTIB [INN];M-3814(nedisertib);CS-0021723;DA-65178;M 3814;peposertibum;(~{S})-[2-chloranyl-4-fluoranyl-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl]-(6-methoxypyridazin-3-yl)methanol;3-Pyridazinemethanol, alpha-(2-chloro-4-fluoro-5-(7-(4-morpholinyl)-4-quinazolinyl)phenyl)-6-methoxy-, (alphaS)-;EX-A1679;3-PYRIDAZINEMETHANOL, .ALPHA.-(2-CHLORO-4-FLUORO-5-(7-(4-MORPHOLINYL)-4-QUINAZOLINYL)PHENYL)-6-METHOXY-, (.ALPHA.S)-;UNII-GN429E725A;(S)-(2-chloro-4-fluoro-5-(7-morpholin-4-ylquinazolin-4-yl)phenyl)-(6-methoxypyridazin-3-yl)methanol;NSC-816960;SCHEMBL16235559;MSC 2490484A [WHO-DD];CHEMBL4297629;1637542-33-6;1IX;M-3814;NSC-802822;example 136 (WO2014183850);MSC-2490484A;TS-10640
SMILES: ClC1C=C(C(=CC=1[C@@H](C1C=CC(=NN=1)OC)O)C1C2C=CC(=CC=2N=CN=1)N1CCOCC1)F
Formula: C24H21ClFN5O3
M.Wt: 481.9066
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC70085 Nedisertib (Synonyms: Peposertib; M3814) Nedisertib (M3814, MSC2490484A) is a highly potent, selective, orally bioavailable inhibitor of DNA-PK.
DC46491 BAY-8400 BAY-8400 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor with IC50 of 81 nM. BAY-8400 shows synergistic activity of DNA-PK inhibition when combined with DNA damage inducing cancer therapy, like targeted alpha radiation.
DC3113 KU-0060648 KU 0060648 is a potent and selective inhibitor of DNA-dependent protein kinase (DNA-PK), (IC50 = 8.6 nM); with 20-1000 fold selectivity for DNA-PK over other PIKKs and a panel of 60 kinases.
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