GSK963|RIP1 kinase inhibitor|CAS 2049868-46-2

Cas No.:	2049868-46-2
Chemical Name:	GSK963
Synonyms:	GSK963;GSK-963;GSK 963
SMILES:	CC(C(=O)N1[C@H](C2C=CC=CC=2)CC=N1)(C)C
Formula:	C₁₄H₁₈N₂O
M.Wt:	230.31
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.

Description:

GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].

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