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GSK2606414

Cat. No.: DC7142 Featured

Chemical Structure

1337531-36-8

For research use only. We do not sell to patients.

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Field of application

GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	1337531-36-8
Chemical Name:	7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyrimidin-4-amine
Synonyms:	GSK2606414,GSK-2606414,GSK 2606414
SMILES:	C1=CC(C2C3C(N)=NC=NC=3N(C)C=2)=CC2CCN(C(=O)CC3=CC=CC(C(F)(F)F)=C3)C1=2
Formula:	C₂₄H₂₀F₃N₅O
M.Wt:	451.44
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	GSK2606414 is a cell-permeable and orally available PERK inhibitor with an IC50 of 0.4 nM.
In Vivo:	GSK2606414 (50 and 150 mg/kg, p.o.) inhibits the growth of a human tumor xenograft in mice[1].
In Vitro:	GSK2606414 inhibits PERK activation in cells[1].

Cat. No.	Product name	Field of application
DC7431	ISRIB	ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective PERK inhibitor with IC50 of 5 nM.
DC7142	GSK2606414	GSK2606414 is an orally available, potent, and selective PERK inhibitor with an IC50 of 0.4 nM.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.